Origin of multicellularity in animals: identification and analysis of intercellular signalling pathways in a basal metazoan, the demosponge Reniera

动物多细胞性的起源：基础后生动物（demosponge Reniera）细胞间信号通路的识别和分析

• 批准号: DP0667070
• 负责人: A/Prof Daniel Jackson
• 金额: $ 14.2万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0667070
• 关键词: Origin; multicellularity; animals; identification; analysis

The Reniera genome project is a multi-million dollar collaboration between JGI (US-DOE) and Australian scientists that will see the sequencing of the first Australian marine animal by 2006. This project will significantly advance our understanding of the origins of animals and contribute to the reconstruction of creatures that lived over 600 million years ago. A major outcome of this reconstruction will be a fundamental understanding of how cells communicate with each other during the process of development to give rise to the diversity of cell types within multicellular animals. This study will also shed light on what happens when cell communication goes astray, as observed in a range of human malignancies, including cancer.

Reniera基因组计划是JGI（美国能源部）和澳大利亚科学家之间的一项耗资数百万美元的合作项目，将在2006年对澳大利亚的第一个海洋动物进行测序。这个项目将极大地促进我们对动物起源的理解，并有助于重建生活在6亿多年前的生物。这种重建的一个主要成果将是对细胞在发育过程中如何相互沟通的基本理解，从而在多细胞动物中产生细胞类型的多样性。这项研究还将揭示当细胞通讯出现错误时会发生什么，正如在包括癌症在内的一系列人类恶性肿瘤中观察到的那样。