Function of the receptor for advanced glycation end products (RAGE) in inflammation-associated liver carcinogenesis (A05)

A05项目（Angel/Damle-Vartak；晚期糖基化终产物受体（RAGE）在炎症相关肝癌发生中的功能）已经证明了RAGE在肝祖细胞（LPC）扩张中的内在和外在作用，以及LPC-星状细胞互扰诱导纤维化和肝癌发生的作用。在新的资助期内，RAGE在癌前病变和hcc形成中的作用将通过有条件的RAGE删除来评估。将特别强调肿瘤相关免疫反应的影响，LPC异质性和肿瘤衍生的微环境重塑聚焦于胆道网络，使用亚细胞分辨率的三维共聚焦成像在癌前病变和发展中的肿瘤。与人类hcc的比较将揭示RAGE与lpc相关的导管反应和肝癌发生的相关性。

Project A05 (Angel/Damle-Vartak; Function of the receptor for advanced glycation end products (RAGE) in inflammation-associated liver carcinogenesis) has demonstrated the intrinsic and extrinsic roles of RAGE for the expansion of liver progenitor cells (LPC), LPC-stellate cell-crosstalk for induction of fibrosis and hepatocarcinogenesis. In the new funding period the role of RAGE for the formation of premalignant lesions and HCCs will be assessed by conditional RAGE deletion. Specific emphasis will be given to the impact of the tumor-associated immune response, LPC heterogeneity and the tumor-derived remodeling of the microenvironment focusing on the biliary network using 3D confocal imaging at subcellular resolution in premalignant lesions and developed tumors. Comparison with human HCCs will unravel the relevance of RAGE for LPC-associated ductular reaction and hepatocarcinogenesis.