Function of the receptor for advanced glycation end products (RAGE) in inflammation-associated liver carcinogenesis (A05)

点击翻译按钮获取中文摘要

Project A05 (Angel/Damle-Vartak; Function of the receptor for advanced glycation end products (RAGE) in inflammation-associated liver carcinogenesis) has demonstrated the intrinsic and extrinsic roles of RAGE for the expansion of liver progenitor cells (LPC), LPC-stellate cell-crosstalk for induction of fibrosis and hepatocarcinogenesis. In the new funding period the role of RAGE for the formation of premalignant lesions and HCCs will be assessed by conditional RAGE deletion. Specific emphasis will be given to the impact of the tumor-associated immune response, LPC heterogeneity and the tumor-derived remodeling of the microenvironment focusing on the biliary network using 3D confocal imaging at subcellular resolution in premalignant lesions and developed tumors. Comparison with human HCCs will unravel the relevance of RAGE for LPC-associated ductular reaction and hepatocarcinogenesis.