Synthetic biology tools for integration into bacterial chromosomes

用于整合到细菌染色体中的合成生物学工具

• 批准号: DP160101450
• 负责人: A/Prof Keith Shearwin
• 金额: $ 28.75万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2020-02-29
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160101450
• 关键词: Synthetic; biology; tools; integration; into

The aim of the project is to develop a set of versatile chromosomal integration tools for bacteria, enabling rapid development of novel biological outputs. A major goal in the emerging discipline of synthetic biology is to apply engineering principles to the design and construction of new biological entities such as proteins, genetic circuits and cells. Custom-designed genetic circuits, integrated in an appropriate host genome, hold enormous economic potential for applications ranging from biomedicine to biofuel production. This project aims to help synthetic biologists to embed made-to-order circuits in appropriate host cells to act as living factories, potentially replacing industrial processes which are currently environmentally and economically costly.

该项目的目的是为细菌开发一套通用的染色体整合工具，从而能够快速开发新的生物产品。合成生物学新兴学科的一个主要目标是将工程原理应用于设计和构建新的生物实体，如蛋白质，遗传电路和细胞。定制设计的基因电路，整合在适当的宿主基因组中，在从生物医学到生物燃料生产的应用中具有巨大的经济潜力。该项目旨在帮助合成生物学家将定制电路嵌入适当的宿主细胞中，作为活工厂，有可能取代目前环境和经济成本高昂的工业过程。