Rational design of genetic circuits that respond to transient signals

响应瞬态信号的遗传电路的合理设计

• 批准号: DP150103009
• 负责人: A/Prof Keith Shearwin
• 金额: $ 16.67万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150103009
• 关键词: Rational; design; genetic; circuits; respond

Engineered genetic circuits with predictable and robust behaviour promise unprecedented environmental and economic benefits. Yet much work remains to be done before living devices can routinely be built from a standarised set of biological parts - the goal of synthetic biologists. By studying how natural genetic switch circuits respond to transient signals, this project aims to uncover a set of design rules which could be used to construct and control purpose-built genetic networks and pathways. The results of this project are expected to add to the molecular tookit available to synthetic biologists.

具有可预测和稳健行为的工程基因电路有望带来前所未有的环境和经济效益。然而，在利用一组标准化的生物部件常规地制造出生命装置之前，还有很多工作要做——这是合成生物学家的目标。通过研究自然遗传开关电路如何响应瞬态信号，该项目旨在揭示一组可用于构建和控制专门构建的遗传网络和通路的设计规则。该项目的结果预计将增加合成生物学家可用的分子研究。