Tailored delivery of anti-inflammatory natural drugs using polymer-based nanocarriers to prevent cytokine and eicosanoid storms in infectious inflammation (C02)

抗炎药物将被评估为干扰脓毒症和新冠肺炎等感染性炎症中的细胞因子和二十烷类风暴。它们将通过应用具有不同隐形部分的聚合物纳米颗粒的新的可持续技术和用于治疗M1/M2巨噬细胞和SARS-CoV-2感染的上皮细胞的特定靶向策略来包裹。使用微流控生物芯片、无壳鸡蛋S蛋和小鼠腹膜炎模型，将评估环境因素的影响。

Anti-inflammatory drugs will be evaluated for interfering with cytokine and eicosanoid storms in infectious inflammation such as sepsis and Covid-19. They will be encapsulated by appying new sustainable techniques for polymeric nanoparticles with different stealth moieties and specific targeting strategies for the treatment of M1 / M2 macrophages and SARS-CoV-2-infected epithelial cells. Using microfluidic biochips, a shell-less hen´s egg, and a murine peritonitis model, the influence of environmental factors will be evaluated.