NET - Genetics of PTSD: Genetic characteristics of patients with and without symptoms of post-traumatic stress disorder following an intensive care experience

NET - PTSD 的遗传学：在重症监护经历后有或没有创伤后应激障碍症状的患者的遗传特征

• 批准号: 388931134
• 负责人: Professor Dr. Jochen Gensichen
• 金额: --
• 依托单位: Institut für Psychiatrische Phänomik und Genomik
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/388931134?language=en
• 关键词: NET; Genetics; PTSD; Genetic; characteristics

NET-Genetics of PTSD is submitted as a supplementary grant application to the clinical trial NET (Narrative Exposure Therapy) -primary care -Caring for patients with traumatic stress sequelae following intensive medical care (DFG no.: GE2073). The aim of the sub-study is to confirm and add to previous genetic findings associated with symptoms of posttraumatic stress disorder (PTSD) in a unique and particularly well characterized population of patients recruited at Intensive Care Units (ICUs). Treatment at an ICU can be a very disturbing experience due to invasive medical procedures, ventilation, the feeling of helplessness, noise, lights, a disordered sleep rhythm, fear of dying etc. Thus, many patients suffer from long-term functional, medical, or psychological sequelae after discharge. Among psychiatric disorders, PTSD has a unique position as it is the only disorder in which the initiating factor, the trauma exposure, can be unequivocally identified. A number of genes have been described which may be associated with an increased susceptibility for PTSD. They are part of very plausible biological pathways and apparently play a role in fear conditioning, anxiety behaviour and emotionality. Regulatory systems involved include the hypothalamic-pituitary-adrenal axis (HPA axis or HTPA axis: response to stress), the brain serotonergic system (emotional response, anxiety), and dopaminergic neurotransmission (attention, vigilance, arousal, and sleep). Gene-environment interactions are also of great importance. Our study is among the first to investigate the genetic distinctiveness of ICU-patients with PTSD compared to ICU-patients without PTSD.

NET--创伤后应激障碍遗传学--作为临床试验NET(叙述性暴露疗法)--初级保健--护理重症医疗后创伤性应激后遗症患者的补充赠款申请(DFG编号：GE2073)。这项分研究的目的是确认和补充先前与创伤后应激障碍(PTSD)症状相关的基因发现，这些患者是在重症监护病房(ICU)招募的独特且特征特别好的患者群体中发现的。ICU的治疗可能是一种非常令人不安的经历，原因是侵入性的医疗程序、通风、无助感、噪音、灯光、睡眠节奏紊乱、害怕死亡等。因此，许多患者在出院后会遭受长期的功能、医学或心理后遗症。在精神障碍中，创伤后应激障碍具有独特的地位，因为它是唯一可以明确确定引发因素--创伤暴露--的障碍。已经描述了一些可能与创伤后应激障碍易感性增加有关的基因。它们是非常可信的生物通路的一部分，显然在恐惧条件作用、焦虑行为和情绪化方面发挥作用。涉及的调节系统包括下丘脑-垂体-肾上腺轴(HPA轴或HTPA轴：对压力的反应)、大脑5-羟色胺能系统(情绪反应、焦虑)和多巴胺能神经传递(注意力、警觉性、觉醒和睡眠)。基因与环境的相互作用也非常重要。我们的研究是第一批调查患有创伤后应激障碍的ICU患者与没有PTSD的ICU患者的遗传差异的研究之一。