EXC 2180: Image-Guided and Functionally Instructed Tumor Therapies (iFIT)

EXC 2180：图像引导和功能指导的肿瘤治疗 (iFIT)

• 批准号: 390900677
• 金额: --
• 依托单位: Eberhard Karls Universität Tübingen
• 依托单位国家: 德国
• 项目类别: Clusters of Excellence (ExStra)
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/390900677?language=en
• 关键词: EXC; 2180; Image; Guided; Functionally

Our Cluster of Excellence teams world-leading expertise in three important areas of cancer research which have so far been largely separated. Their combination promises an unprece-dented level of understanding of tumor biology and the development of novel diagnostic and therapeutic approaches for tumor diseases. These areas include A) the identification of "functionally instructed molecular therapies" via functional genomics, B) their combination with and further development of advanced immunotherapies and C) the use of multiparametric imaging techniques to guide tumor therapies and to unravel novel classes of therapeutic targets. The iFIT consortium aims to:- functionally identify biological processes in tumors which can be exploited for the development of novel cancer therapies;- explore immunotherapy resistance using functional genomic screening to develop advanced cancer immunotherapies, particularly combinatorial immunotherapies and combinations with molecularly targeted therapies;- advance multiparametric imaging to quantify and temporally resolve key molecular and immunological processes in tumor maintenance, progression and therapy response by using novel methods and biomarkers to unravel novel classes of therapeutic targets;- personalize function-based molecular and immunotherapies and develop combinations there-of through temporally and spatially resolved image guidance.The University of Tübingen provides an ideal environment to conduct the outlined research. As a result of strategic decisions taken in line with the University’s long-term institutional planning, the fields of research involved in iFIT have achieved top positions in international rankings. Besides the recruitment of leading scientists, a unique scientific infrastructure has been established. Our principal investigators have been working closely together within the scope of the Comprehensive Cancer Center Tübingen-Stuttgart, the German Cancer Consortium, several Collaborative Research Center grants (SFBs) and a DFG Research Unit.Building upon scientific excellence and a solid base of proof-of-concept data, our iFIT cluster aims to develop the University of Tübingen into an internationally visible and competitive center for next-generation image-guided and function-based tumor therapies. We will strategically recruit young investigators and professors who will be positioned at the interface of our major research areas, in order to bring interlinked research to an unprecedented level. Thus, iFIT will enable an imaging-based characterization of tumor biology and image-guided therapies to a yet unprecedented level. In the long-term iFIT promises the development of novel and sustainable cancer therapies and, eventually, a significant prognosis improvement for patients with solid tumors.

我们的卓越团队在癌症研究的三个重要领域拥有世界领先的专业知识，到目前为止，这些领域在很大程度上是分开的。他们的结合保证了对肿瘤生物学的前所未有的理解水平，并为肿瘤疾病开发了新的诊断和治疗方法。这些领域包括A）通过功能基因组学鉴定“功能指导的分子疗法”，B）它们与先进免疫疗法的组合和进一步发展，以及C）使用多参数成像技术来指导肿瘤治疗和揭示新类别的治疗靶点。iFIT联盟的目标是：-在功能上鉴定肿瘤中的生物过程，这些生物过程可用于开发新的癌症疗法;-利用功能基因组筛选探索免疫疗法抗性，以开发先进的癌症免疫疗法，特别是组合免疫疗法和与分子靶向疗法的组合;- 先进的多参数成像，以量化和时间分辨肿瘤维持中的关键分子和免疫过程，通过使用新的方法和生物标志物来揭示新型治疗靶点的进展和治疗反应;-个性化基于功能的分子和免疫疗法，并通过时间和空间分辨的图像引导开发组合。蒂宾根大学为开展所概述的研究提供了理想的环境。由于根据大学的长期机构规划采取的战略决策，iFIT所涉及的研究领域在国际排名中名列前茅。除了招募顶尖科学家外，还建立了独特的科学基础设施。我们的主要研究人员一直在图宾根-斯图加特综合癌症中心、德国癌症联盟、几个合作研究中心赠款（SFB）和DFG研究单位的范围内密切合作。在科学卓越和概念验证数据的坚实基础上，我们的iFIT集群旨在将图宾根大学发展成为下一代图像引导和功能的国际知名和有竞争力的中心，基于肿瘤治疗。我们将战略性地招募年轻的研究人员和教授，他们将被定位在我们的主要研究领域的接口，以使相互关联的研究达到前所未有的水平。因此，iFIT将使基于成像的肿瘤生物学表征和图像引导治疗达到前所未有的水平。从长远来看，iFIT有望开发新型和可持续的癌症疗法，并最终显著改善实体瘤患者的预后。