Understanding Mitotic Telomere Deprotection

了解有丝分裂端粒去保护

• 批准号: DP240101869
• 负责人: Prof Anthony Cesare
• 金额: $ 48.68万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240101869
• 关键词: Understanding; Mitotic; Telomere; Deprotection

This project aims to study telomeres, the DNA and protein structures that protect chromosome ends. During cell division, cells under stress intentionally uncap their telomeres. This project expects to generate new knowledge that challenges the conventional notion of telomeres as static elements, showing instead that telomeres can be dynamic signalling hubs. Expected outcomes of this project include an understanding of the genetic, proteomic, and signalling pathways involved in this novel phenomenon. This should provide significant benefits to our fundamental understanding of biological processes that protect human genomes and provide a valuable dataset for research on telomere biology, DNA repair, and genome stability.

该项目旨在研究端粒，保护染色体末端的DNA和蛋白质结构。在细胞分裂过程中，处于压力下的细胞有意地解开它们的端粒。该项目预计将产生新的知识，挑战端粒作为静态元素的传统概念，相反，端粒可以是动态的信号枢纽。该项目的预期成果包括对这一新现象所涉及的遗传、蛋白质组和信号通路的理解。这将为我们对保护人类基因组的生物学过程的基本理解提供重大益处，并为端粒生物学，DNA修复和基因组稳定性的研究提供有价值的数据集。