Crosstalk between Foxp3+ Regulatory T Cells and Type 2 Immunity in Maintaining Adipose Tissue Homeostasis
Foxp3 调节性 T 细胞与 2 型免疫在维持脂肪组织稳态中的串扰
基本信息
- 批准号:392936699
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:德国
- 项目类别:Research Units
- 财政年份:2017
- 资助国家:德国
- 起止时间:2016-12-31 至 2022-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Emerging evidence is pointing towards a major role of type 2 immunity in maintaining metabolic homeostasis of the lean adipose tissue (AT). In this context, type 2 immune cells such as M2-macrophages, type 2 innate lymphoid cells and eosinophils, as well as cardinal cytokines of type 2 immunity (IL-4, IL-13) appear of particular relevance. Consistently, the manifestation of obesity is accompanied by a switch towards type 1 immunity with enhanced accumulation of M1-polarized macrophages, pathogenic CD4+ and CD8+ T effector cells, and proinflammatory cytokines (TNF, IL-6) that promote insulin resistance of the AT. Notably, a unique subphenotype of CD4+ regulatory T (Treg) cells co-expressing Foxp3 and PPAR- has been shown to be enriched in the lean AT and to critically contribute to the maintenance of AT homeostasis, although the underlying mechanisms have yet to be identified. Conversely, the population size of such AT-residing Treg cells markedly decreases in obesity. Overall, independent lines of evidence have firmly established that AT-residing type 2 immune and Foxp3+ Treg cells resent important players in the control of AT metabolism, while the exact molecular and cellular mechanisms involved have remained ill-defined. In particular, it has remained unclear to what extent type 2 immune cells (e.g. eosinophils) and Treg cells cooperate in maintaining AT homeostasis, and whether naturally induced Foxp3+ Treg cells of thymic and peripheral origin exert specialized functions in this process. These important questions will be addressed in the present proposal.
新出现的证据指向2型免疫在维持瘦脂肪组织(AT)代谢稳态中的主要作用。在这种情况下,2型免疫细胞,如m2 -巨噬细胞、2型先天淋巴样细胞和嗜酸性粒细胞,以及2型免疫的主要细胞因子(IL-4、IL-13)显得特别相关。一致地,肥胖的表现伴随着向1型免疫的转变,m1极化巨噬细胞、致病性CD4+和CD8+ T效应细胞和促炎细胞因子(TNF, IL-6)的积累增强,促进AT的胰岛素抵抗。值得注意的是,共表达Foxp3和PPAR-的CD4+调节性T (Treg)细胞的一种独特亚表型已被证明在瘦AT中富集,并对AT稳态的维持起关键作用,尽管其潜在机制尚未确定。相反,这种at -驻留Treg细胞的群体大小在肥胖中显着减少。总的来说,独立的证据线已经坚定地确立了AT- 2型免疫细胞和Foxp3+ Treg细胞在控制AT代谢中扮演重要角色,而所涉及的确切分子和细胞机制仍然不明确。特别是,目前尚不清楚2型免疫细胞(如嗜酸性粒细胞)和Treg细胞在多大程度上协同维持AT稳态,以及胸腺和外周来源的自然诱导的Foxp3+ Treg细胞是否在这一过程中发挥特殊功能。这些重要的问题将在本建议中讨论。
项目成果
期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Robo4‐mediated pancreatic endothelial integrity decreases inflammation and islet destruction in autoimmune diabetes
Robo4â 介导的胰腺内皮完整性可减少自身免疫性糖尿病中的炎症和胰岛破坏
- DOI:10.1096/fj.201900125rr
- 发表时间:2020
- 期刊:
- 影响因子:0
- 作者:Troullinaki M;Chen LS;Witt A;Pyrina I;Phieler J;Kourtzelis I;Chmelar J;Sprott D;Gercken B;Koutsilieris M;Chavakis T;Chatzigeorgiou A
- 通讯作者:Chatzigeorgiou A
Approaches to Discriminate Naturally Induced Foxp3+ Treg cells of Intra- and Extrathymic Origin: Helios, Neuropilin-1, and Foxp3RFP/GFP
区分胸腺内和胸腺外来源的自然诱导 Foxp3 Treg 细胞的方法:Helios、Neuropilin-1 和 Foxp3RFP/GFP
- DOI:10.4172/2155-9899.1000540
- 发表时间:2018
- 期刊:
- 影响因子:0
- 作者:Dohnke S;Schreiber M;Schallenberg S;Simonetti M;Fischer L;Garbe AI;Chatzigeorgiou A;Kretschmer K
- 通讯作者:Kretschmer K
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Dr. Antonios Chatzigeorgiou其他文献
Dr. Antonios Chatzigeorgiou的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Dr. Antonios Chatzigeorgiou', 18)}}的其他基金
Co-stimulatory interactions in the development of Non-Alcoholic Steatohepatitis and Liver Fibrosis
非酒精性脂肪性肝炎和肝纤维化发展中的共刺激相互作用
- 批准号:
396067872 - 财政年份:2018
- 资助金额:
-- - 项目类别:
Research Grants
相似海外基金
Understanding the interplay between the gut microbiome, behavior and urbanisation in wild birds
了解野生鸟类肠道微生物组、行为和城市化之间的相互作用
- 批准号:
2876993 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
CAREER: Quantifying congruences between modular forms
职业:量化模块化形式之间的同余性
- 批准号:
2337830 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Continuing Grant
CAREER: Closing the Loop between Learning and Communication for Assistive Robot Arms
职业:关闭辅助机器人手臂的学习和交流之间的循环
- 批准号:
2337884 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Standard Grant
Collaborative Research: URoL:ASC: Determining the relationship between genes and ecosystem processes to improve biogeochemical models for nutrient management
合作研究:URoL:ASC:确定基因与生态系统过程之间的关系,以改进营养管理的生物地球化学模型
- 批准号:
2319123 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Standard Grant
Collaborative Research: Geophysical and geochemical investigation of links between the deep and shallow volatile cycles of the Earth
合作研究:地球深层和浅层挥发性循环之间联系的地球物理和地球化学调查
- 批准号:
2333102 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Continuing Grant
Exploration of relationship between floods, poverty, and dynamic environmental sustainability
探索洪水、贫困和动态环境可持续性之间的关系
- 批准号:
24K07692 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Grant-in-Aid for Scientific Research (C)
Investigation of crosstalk between Fanconi Anemia pathway and ATM for novel therapeutic strategies of chemoresistant ALT-positive high-risk neuroblastoma
范可尼贫血通路与 ATM 之间的串扰研究,用于化疗耐药 ALT 阳性高危神经母细胞瘤的新治疗策略
- 批准号:
24K10442 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Grant-in-Aid for Scientific Research (C)
Thwarted Identity: The Missing Link Between Psychopathology and Prejudice
受挫的身份:精神病理学与偏见之间缺失的联系
- 批准号:
DP240100108 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Discovery Projects
Interplay between Aging and Tubulin Posttranslational Modifications
衰老与微管蛋白翻译后修饰之间的相互作用
- 批准号:
24K18114 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Grant-in-Aid for Early-Career Scientists