SFB 1366: Vascular Control of Organ Function

SFB 1366：器官功能的血管控制

• 批准号: 394046768
• 金额: --
• 依托单位: Ruprecht-Karls-Universität Heidelberg
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/394046768?language=en
• 关键词: SFB; 1366; Vascular; Control; Organ

The study of blood pressure regulation, coagulation, inflammation, atherosclerosis as well as angiogenesis marks the five major pillars of vascular research. The recent advances in the understanding of the molecular mechanisms driving organotypic vascular differentiation and function reflect the emergence of a sixth branch of vascular biology, for which we coined the term ’Angioscience’. Angioscience is aimed at (i) unraveling in much greater mechanistic detail the molecular repertoire of organotypically differentiated cells of the vessel wall (not just restricted to endothelial cells) all the way to the single cell level, (ii) elucidating the multidirectional molecular crosstalk of vessel wall cells with the cells of their microenvironment as well as systemic effects controlled by organotypic vasculatures, (iii) dissecting niche functions of organotypic vasculatures, and (iv) unraveling the fate maps of different organotypic vasculatures in health and disease. Based on these conceptual considerations, the CRC 1366 ’Vascular Control of Organ Function’ was inaugurated in 2019 to focus on the active roles of endothelial cells and surrounding mural cells in the control of physiological and pathological processes in organ-specific tissue microenvironments, the so-called vascular niches. Organotypic vascular cells, particularly organ-specific endothelial cells, control vascular niche functions during organ development as well as under diverse physiological and pathophysiological conditions by secreting vascular signaling molecules, the so-called angiokines, as well as by generating and expressing additional angiocrine substances, such as molecules of the extracellular matrix, adhesion molecules and other surface receptors. Therefore, blood vessels exert important regulatory and control functions for the development of disease processes, and they are key targets for novel and advanced therapies for metabolic and inflammatory diseases and cancer (angiotargeted therapies).

血压调节、凝血、炎症、动脉粥样硬化和血管生成是血管研究的五大支柱。最近的进展，在理解的分子机制驱动器官型血管分化和功能，反映了血管生物学的第六个分支，我们创造了一个术语“血管科学”的出现。血管科学的目的是（i）在更大的机械细节解开的分子库器官分化细胞的血管壁（不仅限于内皮细胞）一直到单细胞水平，（ii）阐明血管壁细胞与其微环境细胞的多向分子串扰以及由器官型血管系统控制的全身效应，（iii）解剖器官型血管的生态位功能，以及（iv）解开健康和疾病中不同器官型血管的命运图。基于这些概念上的考虑，CRC 1366“器官功能的血管控制”于2019年启动，重点关注内皮细胞和周围壁细胞在控制器官特异性组织微环境（所谓的血管小生境）中的生理和病理过程中的积极作用。器官型血管细胞，特别是器官特异性内皮细胞，通过分泌血管信号分子，即所谓的血管因子，以及通过产生和表达额外的血管分泌物质，如细胞外基质分子、粘附分子和其他表面受体，在器官发育期间以及在各种生理和病理生理条件下控制血管生态位功能。因此，血管对疾病过程的发展发挥重要的调节和控制功能，并且它们是代谢和炎性疾病以及癌症的新型和先进疗法（血管靶向疗法）的关键靶点。