Membrane platforms in regulated secretion from endothelial cells (A04)

内皮细胞分泌调节的膜平台 (A04)

• 批准号: 394342108
• 金额: --
• 依托单位: Institut für Medizinische Biochemie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/394342108?language=en
• 关键词: Membrane; platforms; regulated; secretion; endothelial

This project addresses how membrane platforms rich in PA and PI(4,5)P2 serve as Weibel-Palade body (WPB) tethering and/or fusion sites, which proteins are required to establish these platforms and how they link to the WPB. In particular, we analyze the contribution of different Rab proteins and Rab effector functions in the late steps of WPB exocytosis.

该项目解决了富含PA和PI（4，5）P2的膜平台如何作为韦伯-帕拉德体（WPB）拴系和/或融合位点，建立这些平台所需的蛋白质以及它们如何连接到WPB。特别是，我们分析了不同的Rab蛋白和Rab效应器功能的WPB胞吐的后期步骤的贡献。