Foundational approach for next-generation personalized cancer therapywith molecular target agents

点击翻译按钮获取中文摘要

With the use of a biosensor based on the principle of Forster resonance energy transfer, we isolated imatinib-resistant cells of Ph-positive acute lymphoid leukemia and explored their properties. Twenty-four signaling pathways were found activated in the resistant cells, among which inhibition of the mevalonate pathway was revealed effective in preventing repopulation of such resistant cells. These results thereby indicate that the combined application of statin may serve to cure Ph-positive acute lymphoid leukemia as well as imatinib-resistant chronic myeloid leukemia.