Visualization of molecular dynamics of epithelial-mesenchymal and mesenchymal-epithelial transition

我们在此鉴定了转录因子8（TCF 8）作为上皮-间充质转化的调节因子，上皮-间充质转化是癌症侵袭/转移和内皮动员至肿瘤血管生成的关键过程。TCF 8调控EMT的分子机制也在癌细胞和内皮细胞中被揭示。此外，还提供了肿瘤微环境的差异产生癌症恶性肿瘤的独特特征的新证据，这可能导致癌症发展的新策略的发展。

We have hereby identified transcription factor 8 (TCF8) as a regulator of epithelial-mesenchymal transition, a critical process in cancer invasion/metastasis and endothelial mobilization to tumor angiogenesis. The molecular mechanisms by which TCF8 governs EMT were also revealed in both cancer cells and endothelial cells. In addition, novel evidence that the difference in the tumor microenvironment yields distinct feature of cancer malignancy is also provided, which might lead to the development of new strategies to cancer development.