The establishment of animal model for sarcopenia and clarification of the mechanism of sarcopenia: An investigation using an animal model for chronic obstructive pulmonary diseases

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We performed comparative analyses for phenotypes and molecular mechanisms between aged CD9/CD81 double knockout mice (DKO), an animal model for chronic obstructive pulmonary diseases and C57BL/6J mice (B6). Soleus muscle (SOL) mass was lower in DKO than in B6, however there was no difference in extensor digitorum longus muscle (EDL) mass between DKO and B6. The comprehensive genetic analysis using both muscle revealed the elevation of gene expressions related to apoptosis and inflammation in SOL and the change of gene expressions related to muscle protein synthesis in EDL of DKO. These findings suggest that DKO shows different gene-expression patterns among muscle fiber types.