Development of a novel MRI contrast medium toward detection of hypoxic lesions and quantification of partial oxygen pressure

开发一种新型 MRI 造影剂，用于检测缺氧病变和量化氧分压

• 批准号: 23659197
• 负责人: FUKUMOTO Manabu
• 金额: $ 2.58万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23659197/
• 关键词: 低酸素; ナノ粒子; MRI; がん幹細胞; がん治療

In order to eradicate cancer, we need establish diagnostic and therapeutic methods specially targeting hypoxic lesions. We intended to develop contrast medium for MRI composed of oxide iron nanoparticles which can seek for hypoxic lesions. In vitro study that these nanoparticles were ingested into cancer cells under hypoxic conditions and revealed cytotoxic property. Using transplanted tumors into mice, we will evaluate the in vivo potential of the oxide nanoparticles.

为了根除肿瘤，我们需要建立专门针对缺氧病变的诊断和治疗方法。我们打算开发由氧化铁纳米颗粒组成的MRI造影剂，可以寻找缺氧病变。在体外研究中，这些纳米颗粒在缺氧条件下被摄入癌细胞中，并显示出细胞毒性。使用移植到小鼠体内的肿瘤，我们将评估氧化物纳米颗粒的体内潜力。

项目成果

A narrow microbeam is more effective for tumor growth suppression than a wide microbeam: an in vivo study using implanted human glioma cells.

• DOI: 10.1107/s090904951101185x
• 发表时间: 2011-07
• 期刊: Journal of synchrotron radiation
• 影响因子: 2.5
• 作者: Uyama A;Kondoh T;Nariyama N;Umetani K;Fukumoto M;Shinohara K;Kohmura E
• 通讯作者: Kohmura E

糸状菌の界面活性タンパク質による生分解生プラスチックの新規分解促進機構とその応用

丝状真菌表面活性蛋白促进生物降解塑料降解的新机制及其应用

• 发表时间: 2012
• 作者: 高橋徹;阿部敬悦
• 通讯作者: 阿部敬悦

Activation of the EGFR, AKT and ERK1/2 by exposure to tritiated water in human tumor cells

接触氚化水可激活人肿瘤细胞中的 EGFR、AKT 和 ERK1/2

• 发表时间: 2011
• 期刊: Fusion Sci Technol
• 影响因子: 0.9
• 作者: Shimura T;Kuwahara Y;Fukumoto M;Umata T
• 通讯作者: Umata T

Invariant NKT cells recognize glycolipids from pathogenic gram-positive bacteria

不变的 NKT 细胞识别致病性革兰氏阳性菌的糖脂

• 发表时间: 2011
• 期刊: Nat. Immunol
• 作者: Kinjo Y;Illarionov P;Pei B;Vela JL;Girardi E;Li X;Li Y;Imamura M;Rogers P;Uchiyama S;Khurana A;Ainge GD;Gibson D;Kawahara K;Nizet V;Yesilkaya V;Andrew P;Wong CH;Painter G;Kawakami K;Besra GS;Tsuji M;Zajonc DM;Kronenberg M
• 通讯作者: Kronenberg M

Synthesis of surface-modified monoclinic ZrO2 nanoparticles using supercritical water

• DOI: 10.1039/c2ce06409j
• 发表时间: 2012-02
• 期刊: CrystEngComm
• 影响因子: 3.1