Development of a novel MRI contrast medium toward detection of hypoxic lesions and quantification of partial oxygen pressure

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In order to eradicate cancer, we need establish diagnostic and therapeutic methods specially targeting hypoxic lesions. We intended to develop contrast medium for MRI composed of oxide iron nanoparticles which can seek for hypoxic lesions. In vitro study that these nanoparticles were ingested into cancer cells under hypoxic conditions and revealed cytotoxic property. Using transplanted tumors into mice, we will evaluate the in vivo potential of the oxide nanoparticles.