Development of the new vascular occlusion coil using atelocollagen for the noxious and abnormal vessels.

使用去端肽胶原开发新型血管闭塞线圈，用于治疗有害和异常血管。

• 批准号: 23659387
• 负责人: KISHIRO Masahiko
• 金额: $ 2.33万
• 依托单位: Juntendo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23659387/
• 关键词: 代替医療; アテロコラーゲン; コラーゲン液状血管閉鎖栓; カテーテル治療; 動物実験; 自己組織化; New deviceの開発; 血管閉塞術; 液体状血管塞栓; コラーゲン血管閉鎖栓; 液状血管塞栓物質; コラーゲンステント

Atelocollagen coil development which was New device in the noxious and abnormal blood vessel embolectomy was planned,and for the impossible,the coil manufacture newly drafted the development of liquid vascular occlusion plug using the collagen solution at present.The atelocollagen implant,ACI of KOUKEN CO.LTD.changes over 37'C from the liquid to the elasticity gel,and it has been used as lachrymal gland closure plug and skin collapse filler practically.The delivery system which stored ACI to abnormal blood vessel was amended in the system for injecting direct ACI in the catheter diameter 5Fr.the above tip hole style.For In vitro experiment and plan correction and design,the animal experiment start by the rabbit was drastically retarded.In the future,the animal experiment will be advanced in as planned in the beginning.

计划开发用于有害和异常血管栓子切除术的新器械--去端胶原弹簧圈，由于不可能，目前弹簧圈制造商重新拟定了使用胶原溶液的液体血管闭塞塞的开发。KOUKEN CO.LTD的去端胶原植入物ACI在37 ℃以上从液体变为弹性凝胶，将ACI贮存到异常血管的输送系统修改为直接注射ACI的系统，导管直径为5 Fr，上述尖端孔样式。通过体外实验和方案的修正和设计，使家兔启动的动物实验大大推迟，今后动物实验将按计划提前启动。