Neural correlates of body dissatisfaction: A Functional MRI study.

进食障碍是一种病因不明的疾病，往往会影响年轻女性。身体不满意是神经性厌食症（AN）的重要因素。然而，AN中身体不满的功能神经解剖学在很大程度上是未知的。本研究调查了体形比较，以建立神经相关的身体不满的患者AN。在恢复AN组的体形比较诱导更多的激活左舌回，左梭状体区和左杏仁核时，受试者比较自己的体形与苗条的女性身体的图像。视觉皮层的反应反映了他们对他人身体的关注。与焦虑相关的大脑网络是由自我比较他人的形象引起的，可能与他们隐藏的剩余身体不满有关，因此与饮食失调的高复发率有关。这些结果有助于阐明进食障碍患者的生物病理学。

Eating disorders are disorders of unknown etiology that tend to affect young women. Body dissatisfaction is an important factor in anorexia nervosa (AN). However, the functional neuroanatomy of body dissatisfaction in AN is largely unknown. This study has investigated body-shape comparison to establish neural correlates of body dissatisfaction in patients with AN.In the recovered AN group the body-shape comparison induced more activation of the left lingual gyrus, left fusiform body area and left amygdala when subjects compared their own body-shape with images of slim female bodies. The visual cortex responses reflect their concern about the bodies of others. Brain networks associated with anxiety that was induced by self-comparison to others' images may be involved in their hidden remaining body dissatisfaction and hence with the high relapse rate of eating disorders. The results are be helpful in that they shed light on the biological pathology of patients with eating disorders.