Neural correlates of body dissatisfaction: A Functional MRI study.

饮食失调是一种病因不明的失调，往往影响年轻女性。身体不满意是神经性厌食症的一个重要因素。然而，AN中身体不满的功能神经解剖学在很大程度上是未知的。本研究通过比较体型来确定AN患者身体不满意的神经相关因素。在恢复的AN组中，当被试将自己的体型与苗条的女性身体图像进行比较时，体型比较引起了左侧舌回、左侧梭状体和左侧杏仁核的更多激活。视觉皮层的反应反映了他们对他人身体的关注。与自我比较他人形象引起的焦虑相关的大脑网络可能与他们隐藏的剩余身体不满有关，因此饮食失调的复发率很高。这些结果很有帮助，因为它们揭示了饮食失调患者的生物学病理。

Eating disorders are disorders of unknown etiology that tend to affect young women. Body dissatisfaction is an important factor in anorexia nervosa (AN). However, the functional neuroanatomy of body dissatisfaction in AN is largely unknown. This study has investigated body-shape comparison to establish neural correlates of body dissatisfaction in patients with AN.In the recovered AN group the body-shape comparison induced more activation of the left lingual gyrus, left fusiform body area and left amygdala when subjects compared their own body-shape with images of slim female bodies. The visual cortex responses reflect their concern about the bodies of others. Brain networks associated with anxiety that was induced by self-comparison to others' images may be involved in their hidden remaining body dissatisfaction and hence with the high relapse rate of eating disorders. The results are be helpful in that they shed light on the biological pathology of patients with eating disorders.