Neural correlates of body comparison and weight estimation in weight-recovered anorexia nervosa: a functional magnetic resonance imaging study.
Neural correlates of body comparison and weight estimation in weight-recovered anorexia nervosa: a functional magnetic resonance imaging study.
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DOI：
10.1186/s13030-018-0134-z
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发表时间：
2018
影响因子：
2.1
通讯作者：
Komaki G
中科院分区：
文献类型：
--
作者：
Kodama N;Moriguchi Y;Takeda A;Maeda M;Ando T;Kikuchi H;Gondo M;Adachi H;Komaki G
神经性厌食症（AN）患者由社会比较引起的身体不满和情绪问题的神经机制目前尚不清楚。在这里，我们用功能磁共振成像（fMRI）阐明了AN （recAN）康复患者在身体比较和体重估计期间的大脑激活模式。我们使用功能磁共振成像检查了12名recAN患者和13名健康对照者，同时他们对体重过轻、健康和超重的女性身体图像进行了身体比较和体重估计任务。在身体比较任务中，参与者在将自己的身体与所呈现的图像进行比较时，对自己的焦虑程度进行评级。在体重估计任务中，参与者估计所呈现图像中身体的重量。我们使用血氧水平依赖（BOLD）信号的组间感兴趣区域（ROI）分析来分析组间大脑激活模式的差异。此外，为了研究预定roi之外的激活，我们进行了探索性的全脑分析，以确定组间差异。我们发现，与健康对照相比，患有recAN的患者在将自己的身体与体重过轻的女性身体的图像进行比较时，其生殖前扣带皮层（pgACC）的激活明显更大。此外，我们发现，与健康对照相比，recAN患者在比较自己的身体时，无论体重如何，在自我与他人的体型比较中，与胃外体区（EBA）对应的中颞回的激活明显更小。我们对一组recAN患者的研究结果表明，AN的病理可能在于无法通过在身体比较期间激活pgACC来调节对身体图像的负面影响。研究结果还表明，即使在AN康复后，大脑中身体图像处理的改变仍然存在。本文的在线版本（10.1186/s13030-018-0134-z）包含补充内容，仅供授权用户使用。
The neural mechanisms underlying body dissatisfaction and emotional problems evoked by social comparisons in patients with anorexia nervosa (AN) are currently unclear. Here, we elucidate patterns of brain activation among recovered patients with AN (recAN) during body comparison and weight estimation with functional magnetic resonance imaging (fMRI). We used fMRI to examine 12 patients with recAN and 13 healthy controls while they performed body comparison and weight estimation tasks with images of underweight, healthy weight, and overweight female bodies. In the body comparison task, participants rated their anxiety levels while comparing their own body with the presented image. In the weight estimation task, participants estimated the weight of the body in the presented image. We used between-group region of interest (ROI) analyses of the blood oxygen level dependent (BOLD) signal to analyze differences in brain activation patterns between the groups. In addition, to investigate activation outside predetermined ROIs, we performed an exploratory whole-brain analysis to identify group differences. We found that, compared to healthy controls, patients with recAN exhibited significantly greater activation in the pregenual anterior cingulate cortex (pgACC) when comparing their own bodies with images of underweight female bodies. In addition, we found that, compared with healthy controls, patients with recAN exhibited significantly smaller activation in the middle temporal gyrus corresponding to the extrastriate body area (EBA) when comparing their own bodies, irrespective of weight, during self-other comparisons of body shape. Our findings from a group of patients with recAN suggest that the pathology of AN may lie in an inability to regulate negative affect in response to body images via pgACC activation during body comparisons. The findings also suggest that altered body image processing in the brain persists even after recovery from AN. The online version of this article (10.1186/s13030-018-0134-z) contains supplementary material, which is available to authorized users.
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