New biomarker discovery for patients with pulmonary hypertension

肺动脉高压患者的新生物标志物发现

• 批准号: 23659408
• 负责人: SATOH Kimio
• 金额: $ 2.33万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23659408/
• 关键词: 肺高血圧; 低酸素; 酸化ストレス; バイオマーカー; 低酸素環境; 炎症; 血管平滑筋細胞; 臨床応用; サイクロフィリンA; Rho-kinase

Pulmonary hypertension (PH) is associated with hypoxic exposure, enhanced production of reactive oxygen species (ROS) and proliferation of vascular smooth muscle cells (VSMC). In this study, we tested our hypothesis that cyclophilin A (CyPA) contributes to pulmonary vascular remodeling in patients with PH. Plasma CyPA levels were significantly elevated in patients with PH than in those without PH or healthy controls. Moreover, plasma CyPA levels increased according to the quartiles of pulmonary vascular resistance. Medical treatments reduced plasma CyPA levels in patients with PH. Finally, event-free curve revealed that high plasma CyPA predicted poor outcome (death or lungtransplantation). These results indicate that plasma CyPA is a novel biomarker for patients with PH.

肺动脉高压（PH）与低氧暴露、活性氧（ROS）产生增加和血管平滑肌细胞（VSMC）增殖有关。在这项研究中，我们测试了我们的假设，亲环素A（CyPA）有助于肺血管重塑PH患者。血浆CyPA水平显着升高PH患者比那些没有PH或健康对照组。此外，血浆CyPA水平根据肺血管阻力的四分位数增加。药物治疗降低了PH患者的血浆CyPA水平。最后，无事件曲线显示，血浆CyPA水平高预示预后不良（死亡或肺移植）。这些结果表明，血浆CyPA是PH患者的新生物标志物。

项目成果

Prognostic impact of myocardial interstitial fibrosis innon-ischemic heart failure -

心肌间质纤维化对非缺血性心力衰竭的预后影响 -

• 发表时间: 2011
• 期刊: Comparisonbetween preserved and reduced ejectionfraction heart failure- Circ J
• 作者: Aoki T;Fukumoto Y;Sugimura K;Oikawa M;Satoh K;Nakano M;Nakayama M;Shimokawa H
• 通讯作者: Shimokawa H

Recent research progress on the role of Rho-kinase pathway in the pathogenesis of pulmonary arterial hypertension -From Bench to Bedside-

Rho激酶通路在肺动脉高压发病机制中作用的最新研究进展-From Bench to Bedside-

• 发表时间: 2013
• 作者: Fukumoto Y;Sugimura K;Shimizu T;Qiqige Z;Yamamoto S;Tatebe S;Aoki T;Nochioka K;Miura Y;Satoh K;Shimokawa H
• 通讯作者: Shimokawa H

酸化ストレス分泌蛋白CyclophylinAによる肺高血圧促進機構-Rho-kinase系の関与-

氧化应激分泌蛋白CyclophylinA促进肺动脉高压的机制 - Rho激酶系统的参与 -

• 发表时间: 2012
• 作者: 佐藤公雄;福本義弘;杉村宏一郎;三浦裕;青木竜男;後岡広太郎;建部俊介;山本沙織;清水亨;下川宏明
• 通讯作者: 下川宏明

Spontaneous development of arrhythmogenic right ventricular cardiomyopathy in mice overexpressing dominant-negative Rho-kinase in vascular smooth muscle cells. (#10984)

血管平滑肌细胞中显性失活 Rho 激酶过度表达的小鼠自发发生致心律失常性右心室心肌病。

• 发表时间: 2012
• 作者: Ellawindy A;Satoh K;Tanaka S;Ikeda S;Shimizu T;Noda K;Fukumoto Y;KobayashiK;NakayamaK,Shimokawa H
• 通讯作者: NakayamaK,Shimokawa H

Increased incidence of heart failure in the East Japan Earthquake Disaster

东日本地震灾害中心力衰竭发病率增加

• 发表时间: 2012
• 作者: Aoki T;Fukumoto Y;Sugimura K;Satoh K;Miura Y;Nochioka K;Tatebe S;Yamamoto S;Shimokawa H
• 通讯作者: Shimokawa H