New biomarker discovery for patients with pulmonary hypertension

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Pulmonary hypertension (PH) is associated with hypoxic exposure, enhanced production of reactive oxygen species (ROS) and proliferation of vascular smooth muscle cells (VSMC). In this study, we tested our hypothesis that cyclophilin A (CyPA) contributes to pulmonary vascular remodeling in patients with PH. Plasma CyPA levels were significantly elevated in patients with PH than in those without PH or healthy controls. Moreover, plasma CyPA levels increased according to the quartiles of pulmonary vascular resistance. Medical treatments reduced plasma CyPA levels in patients with PH. Finally, event-free curve revealed that high plasma CyPA predicted poor outcome (death or lungtransplantation). These results indicate that plasma CyPA is a novel biomarker for patients with PH.