Cyclophilin A Mediates Pulmonary Vascular Remodeling by Rho-kinase Activation in Patients with Pulmonary Hypertension
Cyclophilin A Mediates Pulmonary Vascular Remodeling by Rho-kinase Activation in Patients with Pulmonary Hypertension
批准号:
21790698
负责人:
SATOH Kimio
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
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英文摘要
We tested the hypothesis that CyPA contributes to pulmonary vascular remodeling in PAH patients. Our results provide the direct evidence that the CyPA/Rho-kinase pathway plays an important role in the pathogenesis of PAH in humans.
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DOI:
10.1161/atvbaha.110.214601
发表时间:
2011-05
期刊:
Arteriosclerosis, thrombosis, and vascular biology
影响因子:
--
作者:
[Satoh K, Nigro P, Zeidan A, Soe NN, Jaffré F, Oikawa M, O'Dell MR, Cui Z, Menon P, Lu Y, Mohan A, Yan C, Blaxall BC, Berk BC]
通讯作者:
Berk BC
Cyclophilin A is an inflammatory mediator that promotes atherosclerosis.
亲环蛋白A是一种促进动脉粥样硬化的炎症介质。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Satoh K, et al., 佐藤公雄, 佐藤公雄, 佐藤公雄]
通讯作者:
佐藤公雄
DOI:
10.1253/circj.cj-10-0270
发表时间:
2010-09-01
期刊:
CIRCULATION JOURNAL
影响因子:
3.3
作者:
[Miura, Yutaka, Fukumoto, Yoshihiro, Shimokawa, Hiroaki]
通讯作者:
Shimokawa, Hiroaki
DOI:
10.1084/jem.20101174
发表时间:
2011-01-17
期刊:
The Journal of experimental medicine
影响因子:
--
作者:
[Nigro P, Satoh K, O'Dell MR, Soe NN, Cui Z, Mohan A, Abe J, Alexis JD, Sparks JD, Berk BC]
通讯作者:
Berk BC
血管と酸化ストレス
血管和氧化应激
DOI:
--
发表时间:
2011
期刊:
Angiotensin Research
影响因子:
--
作者:
[Satoh K, Shimokawa H, 佐藤公雄]
通讯作者:
佐藤公雄
共 25 条
Elucidation of the molecular mechanism of the multifaceted action of DOACs through cyclophilin A receptor
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批准号:15K15046
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.33万
-
财政年份:2015
-
负责人:SATOH Kimio
-
依托单位:
The development of novel tools for the diagnosis, prevention, and treatment of cardiovascular diseases based on Cyclophilin A
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批准号:24390193
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.4万
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财政年份:2012
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负责人:SATOH Kimio
-
依托单位:
New biomarker discovery for patients with pulmonary hypertension
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批准号:23659408
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项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.33万
-
财政年份:2011
-
负责人:SATOH Kimio
-
依托单位:
海外基金