Molecular mechanisms of tumorigenesis of enteric and pancreatic neuroendocrine tumor and development of new molecular targeting therapy.

肠胰神经内分泌肿瘤发生的分子机制及新型分子靶向治疗的发展。

• 批准号: 23659638
• 负责人: MIYAZAKI Masaru
• 金额: $ 2.33万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23659638/
• 关键词: 膵臓外科学; 神経内分泌腫瘍; 膵腫瘍; Pdx-1; Ngn-3; 膵内分泌腫瘍; 膵内分泌癌; 転写因子

The aim of this study is to reveal the molecular mechanisms underlying tumorigenesis of pancreatic neuroendocrine tumors (pNET). Reevaluating 33 resected cases revealed that patients with Neuroendocrine carcinoma experienced extremely poor prognosis and the development of new therapy is necessary. Strong expression of Pdxl and Ngn3, which play important role in pancreatic development, in NET cells predicted favorable prognosis. These results indicate that these factors induce tumor cell differentiation. We are now trying the molecular roles of these factors using cell line.

本研究旨在揭示胰腺神经内分泌肿瘤(PNET)发生的分子机制。重新评估33例神经内分泌癌患者的预后极差，开发新的治疗方法是必要的。在胰腺发育中起重要作用的Pdx1和Ngn3在网络细胞中的强表达预示着良好的预后。这些结果表明，这些因素诱导肿瘤细胞分化。我们现在正在使用细胞系来尝试这些因子的分子作用。

项目成果

Hepatocyte apoptosis is enhanced after ischemia/reperfusion in the steatotic liver.

• DOI: 10.3164/jcbn.10-74
• 发表时间: 2011-03
• 期刊: Journal of clinical biochemistry and nutrition
• 影响因子: 2.4
• 作者: Suzuki T;Yoshidome H;Kimura F;Shimizu H;Ohtsuka M;Takeuchi D;Kato A;Furukawa K;Yoshitomi H;Iida A;Dochi T;Miyazaki M
• 通讯作者: Miyazaki M

非典型的な画像所見を呈した非機能性膵神経内分泌腫瘍の1例

影像学表现不典型的无功能胰腺神经内分泌肿瘤一例

• 发表时间: 2011
• 期刊: 日本臨床外科学会雑誌
• 作者: 細川勇;竹内男;大塚将之;吉富秀圭;岸本充;宮崎勝
• 通讯作者: 宮崎勝

CXCR4/CXCL12 expression profile is associated with tumor microenvironment and clinical outcome of liver metastases of colorectal cancer

• DOI: 10.1007/s10585-011-9433-5
• 发表时间: 2012-02-01
• 期刊: CLINICAL & EXPERIMENTAL METASTASIS
• 影响因子: 4
• 作者: Sakai, Nozomu;Yoshidome, Hiroyuki;Miyazaki, Masaru
• 通讯作者: Miyazaki, Masaru

Combination of Preoperative Gemcitabi ne/S-1 Chemotherapy and Aggressive Su rgical Resection for Borderline or In itially Unresectable Locally Advanced Pancreatic Cancer

术前吉西他滨/S-1化疗与积极手术切除相结合治疗交界性或最初不可切除的局部晚期胰腺癌

• 发表时间: 2011
• 作者: Hideyuki Yoshitomi;Fumio Kimura Hiroaki Shimizu Hiroyuki Yoshidome;Masayuki Ohtsuka;Atsushi Kato;Katsunori Furukawa;Dan Takeuchi;Tsukasa Takayashiki;Satoshi Kuboki;Daisuke Suzuki;Masayuki Nakajima;Masaru Miyazaki.
• 通讯作者: Masaru Miyazaki.

進行膵がん治療の新展開 Gemcitabine/S-1療法による切除困難進行膵癌に対する外科切除適応拡大への試み

晚期胰腺癌治疗新进展吉西他滨/S-1疗法扩大难切除晚期胰腺癌手术切除适应证的尝试

• 发表时间: 2011
• 作者: 高原善博;吉富秀幸;高野重紹;賀川真吾;木村文夫;清水宏明;吉留博之;大塚将之;加藤厚;古川勝規;竹内男;高屋敷史;須田浩介;久保木知;賀川真吾;宮崎 勝;Sanae Haga;高原善博;江野村允宏;柳衛宏宣;吉富秀幸
• 通讯作者: 吉富秀幸