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Increased circulating cell signaling phosphoproteins in sera are useful for early detection and the tailor-made therapy for pancreatic and biliary duct cancer patients.

血清中循环细胞信号磷蛋白的增加有助于胰腺癌和胆管癌患者的早期检测和定制治疗。

基本信息

批准号：
21390372
负责人：
MIYAZAKI Masaru
金额：
$ 11.56万
依托单位：
Chiba University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2009
资助国家：
日本
起止时间：
2009 至 2011
项目状态：
已结题

项目摘要

Intracellular phosphoprotein activation significantly regulatescancer progression. We investigated the serum phosphoprotein profile involved in pancreatic cancer by a novel approach that comprehensively measured serum phosphoproteins levels, and clinically applied this method to the detection of pancreatic cancer. We analyzed the serum phosphoproteins that comprised cancer cellular signal pathways by comparing sera from pancreatic cancer patients and benign controls including healthy volunteers and pancreatitis patients. Hierarchical clustering analysis between pancreatic cancer patients and healthy volunteers revealed differential pathway-specific profiles. In particular, the components of the extracellular signal-regulated kinase (ERK) signaling pathway were significantly increased in the sera from pancreatic cancer patients compared with healthy volunteers. The positive rate of p-ERKI/2 (82%) was found to be superior to that of CA19-9 (53%) for early stage pancreatic cancer. For the combination of these serum levels, the area under the receiver-operator-characteristics curves were showing significant ability to distinguish between the two populations in independent validation set, and between cancer and non-cancer populations in another validation set. The comprehensive measurement of serum cell signal phosphoproteins is useful for, the detection of pancreatic cancer. Further investigations will lead to the implementation of tailor-made molecular-targeted therapeutics.

细胞内磷蛋白活化显著调节肿瘤进展。我们通过一种新的方法，全面测量血清磷蛋白水平，研究了胰腺癌相关的血清磷蛋白谱，并将该方法应用于胰腺癌的临床检测。我们通过比较胰腺癌患者和良性对照（包括健康志愿者和胰腺炎患者）的血清，分析了组成癌症细胞信号通路的血清磷蛋白。胰腺癌患者和健康志愿者之间的分层聚类分析显示不同的通路特异性的配置文件。特别是，与健康志愿者相比，胰腺癌患者血清中细胞外信号调节激酶（ERK）信号通路的组分显著增加。p-ERKI/2在早期胰腺癌中的阳性率（82%）高于CA 19 -9（上级）（53%）。对于这些血清水平的组合，受试者-操作者特征曲线下面积显示出区分独立验证集中两个人群以及另一验证集中癌症和非癌症人群的显著能力。血清细胞信号磷蛋白的综合检测有助于胰腺癌的诊断。进一步的研究将导致实施量身定制的分子靶向疗法。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Effects of Partial Hepatic Venous Congesti on on Hepatic

部分肝静脉充血对肝脏的影响

DOI：
发表时间：
2010
期刊：
Hepato-Gastroenterology
影响因子：
0
作者：
Okuno A;Kimura F;Nakagawa K;Shimizu H;Yoshidome H;Ohtsuka M;Kate A;Fukuda T;Miyazaki M
通讯作者：
Miyazaki M

Increased circulating cell signalling phosphoproteins in sera are useful for the detection of pancreatic cancer

DOI：
10.1038/sj.bjc.6605734
发表时间：
2010-07-13
期刊：
BRITISH JOURNAL OF CANCER
影响因子：
8.8
作者：
Takano, S.;Sogawa, K.;Miyazaki, M.
通讯作者：
Miyazaki, M.

One hundred seven consective surgical resections for hilar cholangiocarcinoma of Bismuth types II, III, IV between 2001 and 2008

2001 年至 2008 年间，有 107 例 Bismuth II、III、IV 型肝门部胆管癌连续手术切除

DOI：
发表时间：
2010
期刊：
Japan Hepatobihary Pancreat Science
影响因子：
0
作者：
Kittaka N;Seno S;Takeda Y;Kobayashi S;Marubashi S;Dono K;Umeshita K;Nagano H;Matsuda H;Monden M;Mori M;Doki Y;Miyazaki M
通讯作者：
Miyazaki M

教育セッション7 講師がん治療update

教育会议 7 讲师癌症治疗更新