Exploration of cause of death and acute phase treatment for carbondioxide poisoning

二氧化碳中毒死因探讨及急性期救治

• 批准号: 23659842
• 负责人: MIZUTANI Taro
• 金额: $ 2.33万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23659842/
• 关键词: 急性中毒学; 二酸化炭素中毒; 急性期治療; 中毒モデル; CO2中毒; 急性中毒

The hazardousness is recognized in CO2 poisoning by real cases and disasters, however the mechanism and the direct cause of CO2 poisoning death are not revaeled. To investigate the cause of death, we established model rats and time-dependently measured hemodynamics, blood gas analysis in rats and theconcentration of CO2 and O2 in the chamber. After the sacrifice, we isolated the tissues and analyzed some molecular biological data. This study is very challenging for us to aim to determine the upper limitation of CO2 concentration in the blood and elucidate the mechanism of CO2 poisoning.

真实的案例和灾难已经认识到CO2中毒的危害性，但并未揭示CO2中毒死亡的机制和直接原因。为了调查死亡原因，我们建立了大鼠模型，并随时间测量了大鼠的血流动力学、血气分析以及室内 CO2 和 O2 浓度。处死后，我们分离了组织并分析了一些分子生物学数据。这项研究对于我们来说非常具有挑战性，旨在确定血液中CO2浓度的上限并阐明CO2中毒的机制。