New diagnostic establishment of septic shock complicating endothelial dysfunction

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Septic shock is mortal status for infectious patients. Circulatory, inflammatory and coagulant regulations on the acute phase critically affect their prognosis. However, the effect of potentially underlying endothelial dysfunction has not been revealed. The purpose of this study is to elucidate whether underlying endothelial dysfunction affects the prognosis of the patients after septic shock status or not, and the mechanism of the pathway. Next we aim to establish the new biomarker to the prognosis the patients and discover the new target of therapeutic molecule for the patients.