Long-lasting synaptic plasticity subjected to the stochastic principle

遵循随机原理的持久突触可塑性

• 批准号: 24650207
• 负责人: OGURA Akihiko
• 金额: $ 2.41万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24650207/
• 关键词: シナプス可塑性; シナプス新生; シナプス廃止; ゆらぎ; 脳切片培養; 記憶固定; 構造可塑性

We have proposed that 2 novel synaptic plasticity phenomena in the stable cultures of hippocampal slice should serve as suitable models for the analyses of cellular mechanisms underlying memory consolidation. Those are RISE (long-lasting synaptic enhancement after 3 repeated inductions of LTP supported by new synapse formation) and LOSS (long-lasting synaptic weakening after 3 repeated inductions of LTD supported by synapse elimination). In the present study we demonstrated that RISE develops through the following phases: a) the synapses are under constant generation and retraction; b) both the rates of generation and retraction increase transiently after a RISE-producing stimulus, c) the retraction rate returns to the basal level earlier than the generation rate, leading to a net increase in synapse density. However, LOSS develops without the phase of b. The 2 apparently symmetric phenomena are in fact asymmetric in the process of development.

我们提出，在稳定培养的海马切片中，两种新的突触可塑性现象可以作为分析记忆巩固的细胞机制的合适模型。它们分别是RISE（由新突触形成支持的LTP 3次重复诱导后的持久突触增强）和LOSS（由突触消除支持的LTD 3次重复诱导后的持久突触减弱）。在本研究中，我们证明了RISE的发展经历了以下几个阶段：a)突触的不断产生和收缩；b)在产生上升的刺激后，生成和收缩的速率都短暂增加；c)收缩速率比生成速率更早回到基础水平，导致突触密度的净增加。而LOSS的发展没有b相。这两种表面对称的现象在发展过程中实际上是不对称的。

项目成果

Involvement of the BDNF-TrkB signaling pathway in the long-lasting synaptic plasticity in hippocampal slice cultures

BDNF-TrkB 信号通路参与海马切片培养物的持久突触可塑性

• 发表时间: 2012
• 作者: Sakuragi;S.;Tominaga-Yoshino;K.;Ogura;A.
• 通讯作者: A.

長期記憶の細胞機構解明を目指して

旨在阐明长期记忆的细胞机制

• 发表时间: 2013
• 期刊: 日薬理誌
• 作者: Sakuragi S;Tominaga-Yoshino K;Ogura A;冨永恵子,小倉明彦
• 通讯作者: 冨永恵子,小倉明彦

苔状線維CA3間シナプスで繰り返し長期増強の誘発後に生起する可塑的変化

苔藓纤维 CA3 突触反复诱导长期增强后发生的塑性变化

• 发表时间: 2013
• 作者: 有賀理瑛;冨永-吉野恵子;小倉明彦
• 通讯作者: 小倉明彦

Asymmetric dendritic spine dynamics in the apparently symmetric long-term synaptic plasticity phenomena after repeated LTP/LTD inductions.

重复 LTP/LTD 诱导后明显对称的长期突触可塑性现象中的不对称树突棘动力学。

• 发表时间: 2013
• 作者: Hasegawa;S.;Oe;Y.;Tominaga-Yoshino;K. & Ogura;A.
• 通讯作者: A.

A simplified method to generate serotonergic neurons from mouse embryonic stem and induced pluripotent stem cells

• DOI: 10.1111/j.1471-4159.2012.07724.x
• 发表时间: 2012-07
• 期刊: Journal of Neurochemistry
• 影响因子: 4.7
• 作者: Takeshi Shimada;Y. Takai;Kikuko Shinohara;Atsushi Yamasaki;K. Tominaga-Yoshino;A. Ogura;Akihiro Toi;K. Asano;N. Shintani;Atsuko Hayata-Takano;A. Baba;H. Hashimoto