Development of cell surface modification with PEGylated lipid and external stimulation

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Control of cell function by cell surface modification with functional molecule is a promising way to improve cell therapy. Cell surface modification through the association between cell membrane and PEGylated lipid is suitable for clinical application because PEGylated lipid could be modified on any type of cell and could be modified only by incubating with cells. However, modification efficiency is not high. In this study, ultrasound irradiation or addition of cyclodextrin could improve cell surface modification with PEGylated lipid by inhibiting the formation of PEGyated lipid assembly in the medium.