Development of a multifunctional quantum dot for in vivo tracing of fluorescent labeled cells

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Information supplied from tissue distribution and dynamics of transplanted cells decides the efficiency of cell therapy. Quantum dots (QDs) are useful for labeling cells because of their high fluorescence intensity. In this study, we developed PAMAM dendrimer-conjugated QDs, which could enhance cellular uptake of QDs ; therefore, cells were efficiently labeled by PAMAM dendrimer-conjugated QDs. Moreover, PAMAM conjugation could enhance endosomal escape of QDs, consequently fluorescent intensity in cells could be retained longer.