Development of a novel charged-particle therapy combined with cisplatin-incorporated polymeric micelles

使用小鼠实体瘤进行治疗实验，以开发质子治疗和顺铂之间的新型联合治疗。结果表明，质子治疗联合顺铂与单药治疗相比，对肿瘤生长有明显的抑制作用。对用顺铂掺入的聚合物胶束（CDDP-胶束）处理的肿瘤进行元素分析，以使用常规PIXE分析评估肿瘤组织中药物的浓度，并使用亚毫PIXE分析评估其在肿瘤中的空间分布。结果显示，与顺铂相比，用（CDDP-胶束）处理的肿瘤的药物浓度更高，而对于正常组织，观察到CDDP-胶束和顺铂之间的浓度没有显著差异。这一发现表明，CDDP-胶束不仅提供了上级的治疗效果，而且还减少了常规顺铂与质子治疗联合时引起的副作用。

Therapeutic experiments were performed using a murine solid tumor to develop a novel combined-treatment between proton therapy and cisplatin. The results showed that the proton therapy combined with cisplatin inhibited tumor growth significantly in comparison to their monotherapies. Elemental analysis of the tumor treated with cisplatin-incorporated polymeric micelles (CDDP-micells) was performed to evaluate both concentration of the drug in the tumor tissue using the conventional PIXE analysis and its spatial distribution in the tumor using the submilli-PIXE analysis. The results showed higher drug concentration for the tumor treated with (CDDP-micells) compared to cisplatin whereas no significant difference in the concentration between CDDP-micells and cisplatin was observed for the normal tissue. This finding suggests that CDDP-micells not only provide superior therapeutic efficacy but also reduce side effects caused by conventional cisplatin when combined with proton therapy.