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Development of a novel charged-particle therapy combined with cisplatin-incorporated polymeric micelles

Development of a novel charged-particle therapy combined with cisplatin-incorporated polymeric micelles
结合顺铂聚合胶束开发新型带电粒子疗法
批准号:
24650287
负责人:
TERAKAWA Atsuki
金额:
$2.5万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31

项目摘要

项目成果

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中文摘要
翻译
使用小鼠实体瘤进行治疗实验,以开发质子治疗和顺铂之间的新型联合治疗。结果表明,质子治疗联合顺铂与单药治疗相比,对肿瘤生长有明显的抑制作用。对用顺铂掺入的聚合物胶束(CDDP-胶束)处理的肿瘤进行元素分析,以使用常规PIXE分析评估肿瘤组织中药物的浓度,并使用亚毫PIXE分析评估其在肿瘤中的空间分布。结果显示,与顺铂相比,用(CDDP-胶束)处理的肿瘤的药物浓度更高,而对于正常组织,观察到CDDP-胶束和顺铂之间的浓度没有显著差异。这一发现表明,CDDP-胶束不仅提供了上级的治疗效果,而且还减少了常规顺铂与质子治疗联合时引起的副作用。
英文摘要
Therapeutic experiments were performed using a murine solid tumor to develop a novel combined-treatment between proton therapy and cisplatin. The results showed that the proton therapy combined with cisplatin inhibited tumor growth significantly in comparison to their monotherapies. Elemental analysis of the tumor treated with cisplatin-incorporated polymeric micelles (CDDP-micells) was performed to evaluate both concentration of the drug in the tumor tissue using the conventional PIXE analysis and its spatial distribution in the tumor using the submilli-PIXE analysis. The results showed higher drug concentration for the tumor treated with (CDDP-micells) compared to cisplatin whereas no significant difference in the concentration between CDDP-micells and cisplatin was observed for the normal tissue. This finding suggests that CDDP-micells not only provide superior therapeutic efficacy but also reduce side effects caused by conventional cisplatin when combined with proton therapy.
期刊论文(17)
专著(0)
科研奖励(0)
会议论文
Preliminary Study of Proton Therapy Combined with Cisplatin
质子治疗联合顺铂的初步研究
DOI: --
发表时间: 2012
期刊: CYRIC Annual Report
影响因子: --
作者: [A. TERAKAWA, K. ISHII, et al.]
通讯作者: et al.
PIXE分析法を用いた生体試料中の3次元元素分布画像取得法の開発
利用PIXE分析方法开发生物样品中3D元素分布图像采集方法
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [松山哲生、石井慶造、寺川貴樹, 他]
通讯作者:
腫瘍血流遮断により誘発されたマウス固形腫瘍内の元素分布
肿瘤血流阻断诱导的小鼠实体瘤内的元素分布
DOI: --
发表时间: 2013
期刊: NMCC共同利用成果報告集
影响因子: --
作者: [寺川貴樹、石井慶造、松山成男, 他]
通讯作者:
DOI: --
发表时间: 2012
期刊: NMCC 共同利用研究成果報文集
影响因子: --
作者: [H. SUGAI, K. FUJIKI, K. ISHII, S. MATSUYAMA, A. TERAKAWA, et al., Terakawa A., Terakawa A., 寺川貴樹]
通讯作者: 寺川貴樹
13
    Novel ion-beam therapy technology combined with a vascular disrupting agent based on assessment of treatment effects using a high-resolution PET
    • 批准号:
      23240077
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $32.03万
    • 财政年份:
      2011
    • 负责人:
      TERAKAWA Atsuki
    • 依托单位:
    Development of a novel charged-particle therapy combined with effects of tumor blood flow interruption
    • 批准号:
      22650113
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.17万
    • 财政年份:
      2010
    • 负责人:
      TERAKAWA Atsuki
    • 依托单位:
    Study of the minimally invasive proton therapy combined with anti-cancer drugs and vascular disrupting agents
    • 批准号:
      20300174
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $12.81万
    • 财政年份:
      2008
    • 负责人:
      TERAKAWA Atsuki
    • 依托单位:
    Study of the new minimally-invasive proton therapy with antivascular effects
    • 批准号:
      17300169
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $9.46万
    • 财政年份:
      2005
    • 负责人:
      TERAKAWA Atsuki
    • 依托单位:
    海外基金