Development of a novel charged-particle therapy combined with cisplatin-incorporated polymeric micelles

利用小鼠实体瘤进行了治疗实验，以开发质子治疗和顺铂联合治疗的新方法。结果表明，质子疗法与顺铂联合治疗对肿瘤生长的抑制作用明显优于单独用药。对用顺铂聚合物胶束(CDDP-Micells)治疗的肿瘤进行了元素分析，用常规的PIXE分析评估了药物在肿瘤组织中的浓度，用亚毫升PIXE分析评估了药物在肿瘤中的空间分布。结果表明，CDDP胶束治疗肿瘤的药物浓度高于顺铂，而在正常组织中，CDDP胶束和顺铂的药物浓度没有明显差异。这一发现表明，CDDP胶束不仅提供了优越的治疗效果，而且还减少了常规顺铂与质子疗法联合治疗时所产生的副作用。

Therapeutic experiments were performed using a murine solid tumor to develop a novel combined-treatment between proton therapy and cisplatin. The results showed that the proton therapy combined with cisplatin inhibited tumor growth significantly in comparison to their monotherapies. Elemental analysis of the tumor treated with cisplatin-incorporated polymeric micelles (CDDP-micells) was performed to evaluate both concentration of the drug in the tumor tissue using the conventional PIXE analysis and its spatial distribution in the tumor using the submilli-PIXE analysis. The results showed higher drug concentration for the tumor treated with (CDDP-micells) compared to cisplatin whereas no significant difference in the concentration between CDDP-micells and cisplatin was observed for the normal tissue. This finding suggests that CDDP-micells not only provide superior therapeutic efficacy but also reduce side effects caused by conventional cisplatin when combined with proton therapy.