Development of a novel charged-particle therapy combined with cisplatin-incorporated polymeric micelles

利用小鼠实体瘤进行了治疗实验，开发了质子治疗和顺铂联合治疗的新方法。结果表明，质子治疗联合顺铂治疗较单用治疗明显抑制肿瘤生长。对使用顺铂结合聚合物胶束（cddp -胶束）治疗的肿瘤进行元素分析，使用常规的PIXE分析来评估肿瘤组织中药物的浓度，并使用亚毫微米-PIXE分析来评估其在肿瘤中的空间分布。结果显示，（cddp -胶细胞）治疗肿瘤的药物浓度高于顺铂，而正常组织中cddp -胶细胞与顺铂的药物浓度无显著差异。提示cddp -胶细胞联合质子治疗不仅具有优越的治疗效果，而且可以减少常规顺铂治疗的副作用。

Therapeutic experiments were performed using a murine solid tumor to develop a novel combined-treatment between proton therapy and cisplatin. The results showed that the proton therapy combined with cisplatin inhibited tumor growth significantly in comparison to their monotherapies. Elemental analysis of the tumor treated with cisplatin-incorporated polymeric micelles (CDDP-micells) was performed to evaluate both concentration of the drug in the tumor tissue using the conventional PIXE analysis and its spatial distribution in the tumor using the submilli-PIXE analysis. The results showed higher drug concentration for the tumor treated with (CDDP-micells) compared to cisplatin whereas no significant difference in the concentration between CDDP-micells and cisplatin was observed for the normal tissue. This finding suggests that CDDP-micells not only provide superior therapeutic efficacy but also reduce side effects caused by conventional cisplatin when combined with proton therapy.