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Study of the new minimally-invasive proton therapy with antivascular effects

具有抗血管作用的新型微创质子治疗研究

基本信息

批准号：
17300169
负责人：
TERAKAWA Atsuki
金额：
$ 9.46万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

项目摘要

Antitumor effects of the proton therapy in combination with the combretastatin A-4 derivative, AVE8062 were studied by using NFSa fibrosarooma implanted into the hind legs of C3H/He mice in order to investigate the minimally invasive treatment technique in proton therapy with antivassular effects.The proton therapy facilities for small animals were developed to perform the treatment experiments on the tumor mouse model at Cyclotron and Radioisotope Center (CYRIC), Tohoku University. In addition, proton-irradiation experiments with a dog tumor cell of squamous cell carcinoma were performed to derive the relative biological effectiveness (RBE) of a therapeutic 80-MeV proton beam compared to a gamma ray of ^<6O>Co. The RBE of the 80 MeV proton was 1.4-1.6 at the Bragg peak, 1.1 at the spread-out Bragg peak.The time course of a tumor growth was measured after a single irradiation of the proton beam and/or a single intraperitoneal administration of AVE8062. The proton irradiation provided large antitumor effects such as a tumor volume reduction and a tumor growth delay (TGD) depending on the proton absorbed dose ( 15 or 30 Gy ), while there were not significant differences in TGD between the AVE8062 administration groups ( 5 or 10 mg/kg) and an unirradiated control. The proton irradiation in combination with the AVE8062 administration resulted in the almost same TGD as the monotherapy of proton irradiation. The present results suggest that it is important to optimize the protocol for the combined treatment to provide a larger antitumor effect compared to the monotherapy.

质子疗法与考布他汀A-4衍生物组合的抗肿瘤作用，AVE 8062通过使用NFSa纤维肉瘤植入C3 H/为探讨具有抗血管效应的质子治疗中的微创治疗技术，研制了小动物质子治疗装置，在回旋加速器和放射性同位素上对荷瘤小鼠模型进行了治疗实验东北大学研究中心（CYRIC）此外，对狗鳞状细胞癌肿瘤细胞进行质子辐照实验，以得出治疗性80-MeV质子束与γ-Co射线相比的相对生物有效性（RBE）<6O>。80 MeV质子的RBE在布拉格峰处为1.4-1.6，在质子束的单次照射和/或AVE 8062的单次腹膜内施用后测量肿瘤生长的时间过程。质子照射提供了较大的抗肿瘤作用，如肿瘤体积缩小和肿瘤生长延迟（TGD），这取决于质子吸收剂量（15或30戈伊），而AVE 8062给药组（5或10 mg/kg）和未照射对照组之间的TGD无显著差异。质子照射联合AVE 8062给药导致与质子照射单药治疗几乎相同的TGD。目前的结果表明，重要的是要优化方案的联合治疗，以提供更大的抗肿瘤效果相比，单药治疗。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Basic study on the spot-beam scanning irradiation technique for the CYRIC proton-therapy facilities for small animals

CYRIC小动物质子治疗装置点束扫描照射技术的基础研究

DOI：
发表时间：
2007
期刊：
影响因子：
0
作者：
A. Terakawa ;et. al.;A. Terakawa et. al.;A.Terakawa;寺川貴樹;寺川貴樹;A. Terakawa ed. al.;寺川貴樹;寺川貴樹;宮下拓也;A. Terakawa ed. al.;T. Miyashita ed. al.
通讯作者：
T. Miyashita ed. al.

がんの診断から治療へ CYRICの目指すところ

从癌症诊断到治疗：CYRIC 的目标