Noninvasive biopotential measurement in autonomic nervous system using body surface ring electrode

研制了一种具有超高输入阻抗的同轴双极有源电极样机。采用CBA电极与自行研制的高共模抑制比（CMRR）生物放大器相结合，对膝后区坐骨神经的肌交感神经活动（MSNA）进行了无创测量。同时测量所提出的方法和侵入性显微神经摄影术（MNG）进行。虽然在MNG记录中清楚地观察到间歇性MSNA爆发，但仅在应用改进的基于小波的去噪后才观察到所提出的方法的记录中的爆发样尖峰电位。然而，两个激活期几乎相同，整流和积分爆发的峰值彼此相关。

A prototype of concentric bipolar active (CBA) electrode with ultra-high input impedance was made. The CBA electrode, combined with a separately developed bio-amplifier with high common mode rejection ratio (CMRR), was investigated to measure muscle sympathetic nerve activity (MSNA) noninvasively from sciatic nerve at posterior region of knee. Simultaneous measurement of the proposed approach and invasive microneurography (MNG) was conducted. While intermittent MSNA bursts were observed clearly in the MNG recording, burst-like spike potentials in the recording of the proposed method were observed only after applying a modified Wavelet-based denoising. However, both activated periods were almost the same, and both peak values of the rectified and integrated bursts correlated each other.