Noninvasive biopotential measurement in autonomic nervous system using body surface ring electrode

研制了一种具有超高输入阻抗的同心双极有源（CBA）电极样机。采用CBA电极结合自行研制的高共模抑制比生物放大器（CMRR），对膝关节后侧坐骨神经肌交感神经活动（MSNA）进行了无创测量。同时测量所提出的方法和侵入性微神经造影（MNG）。虽然在MNG记录中可以清楚地观察到间歇性的MSNA爆发，但只有在应用改进的基于小波的去噪后，才可以观察到该方法记录中的爆发样尖峰电位。然而，两个激活周期几乎相同，整流和整合脉冲的峰值都具有相关性。

A prototype of concentric bipolar active (CBA) electrode with ultra-high input impedance was made. The CBA electrode, combined with a separately developed bio-amplifier with high common mode rejection ratio (CMRR), was investigated to measure muscle sympathetic nerve activity (MSNA) noninvasively from sciatic nerve at posterior region of knee. Simultaneous measurement of the proposed approach and invasive microneurography (MNG) was conducted. While intermittent MSNA bursts were observed clearly in the MNG recording, burst-like spike potentials in the recording of the proposed method were observed only after applying a modified Wavelet-based denoising. However, both activated periods were almost the same, and both peak values of the rectified and integrated bursts correlated each other.