The development of inflammatory models with endotoxin and its evaluation
The development of inflammatory models with endotoxin and its evaluation
批准号:
07807209
负责人:
UENO Akinori
金额:
$1.28万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
1995
资助国家:
日本
项目状态:
已结题
起止时间:
1995 至 1996
中文摘要
结果表明,缓激肽可能参与了大鼠皮内注射内毒素后通透性的增加。我们发现,先前给内毒素治疗的大鼠对去- arg9 -缓激肽有降压和收缩反应。从蛋白合成拮抗剂和抑制剂的实验结果来看,这两种反应都是通过新诱导的B1受体介导的。此外,内毒素处理大鼠巨噬细胞也能诱导环氧合酶-2。并通过腹腔或胸膜内注射内毒素建立大鼠炎症模型。
英文摘要
It was shown that bradykinin might involve in the permeability increase with intradermally injected endotoxin in rats. It was found that the hypotensive and contractile responses to des-Arg9-bradykinin were induced in rats previously treated with endotoxin. From the experimental results with antagonists and inhibitors of protein synthesis, it could be concluded that both responses mediated via newly induced B1 receptors. Furthermore, cyclooxygenase-2 was also induced by treatment of rat macrophages with endotoxin. And the inflammatory models was established by the intraperitoneal or intrapleural injection of endotoxin into rats.
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Ueno,A.,et al: "Involvement of bradykinin in endotoxin-induced vascular permeability increase in the skin of rats." Eur,J.Pharmacol.284. 211-214 (1995)
Ueno,A.,et al:“缓激肽参与内毒素诱导的大鼠皮肤血管通透性增加。”
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通讯作者:
Ueno,A.,et al: "The mediators involved in endotoxin-induced vescular permeability increase in the rat and their interactions." Jap.J.Pharmacol. 70. 285-290 (1996)
Ueno,A.,et al:“参与内毒素诱导的大鼠血管通透性增加的介质及其相互作用。”
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Matsumoto, H., Naraba, H., Murakami, M., Kudo, I., Yamaki, K., Ueno, A.and Oh-ichi, S.: "Concordant induction of prostaglandin E2 synthase with cyclooxygenase-2 leads to preferred production of prostaglandin E2 over thrombaxane and prostaglandin D2 in lip
Matsumoto, H.、Naraba, H.、Murakami, M.、Kudo, I.、Yamaki, K.、Ueno, A. 和 Oh-ichi, S.:“前列腺素 E2 合酶与环氧合酶 2 的协调诱导导致
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通讯作者:
Tokumasu, T., Ueno, A.and Oh-ishi, S.: "A hypotensive response induced by des-Arg9-bradykinin in young Brown/Norway rats pretreated with endotoxin." Eur.J.Pharmacl.274. 225-228 (1995)
Tokumasu, T.、Ueno, A. 和 Oh-ishi, S.:“用内毒素预处理的年轻 Brown/Norway 大鼠中 des-Arg9-缓激肽诱导的低血压反应。”
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通讯作者:
Ueno, A.Tokumasu, T., Naraba, H.and Oh-ishi, S.: "The mediators involved in endotoxin-induced vascular permeability increase in the rat and their interactions." Jpn.J.Pharmacol.70. 285-290 (1996)
Ueno, A.Tokumasu, T.、Naraba, H. 和 Oh-ishi, S.:“参与内毒素诱导的大鼠血管通透性增加的介质及其相互作用。”
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共 13 条
Development of Graphene-Coated Electrode and High-Sensitive Measurement System for Non-Invasive Autonomic Electroneurography
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批准号:16K01377
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.0万
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财政年份:2016
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负责人:UENO Akinori
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依托单位:
Noninvasive biopotential measurement in autonomic nervous system using body surface ring electrode
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Research and Development of Capacitive Cardiopulmonary Monitor for Home-healthcare Applications
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财政年份:2009
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负责人:UENO Akinori
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依托单位:
THE RESEARCH FOR THE ROLES OF BRADYKININ RECEPTORS IN THE INFLAMMATORY RESPONSE
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批准号:10672155
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.05万
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财政年份:1998
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负责人:UENO Akinori
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依托单位:
海外基金