Exploring a exercise method to induce brain-derived neurotrophic factor more effectively.

探索更有效诱导脑源性神经营养因子的运动方法。

• 批准号: 24650322
• 负责人: KANEKO Fuminari
• 金额: $ 2.5万
• 依托单位: Sapporo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24650322/
• 关键词: リハビリテーション; 電気刺激; 神経科学; 神経栄養因子; 運動

The present experiment was designed to clarify if the muscular contraction induced by the neuromuscular electrical stimulation (NMES) was effective to produce Brain-derived neurotrophic factor (BDNF) with comparing to voluntary muscular contraction. Healthy normal subjects participated in this study. After preliminarily executed trial experiments, the blood lactate, RER, VE, and serum BDNF concentration during and after exercise were measured and analyzed. Still more subjects were needed to conclude the effect of NMES on BDNF production, upward tendency of serum BDNF concentration during exercise was shown with compared to another condition (voluntary exercise, and sham stimulation).

本实验旨在通过与随意肌肉收缩相比较，阐明神经肌肉电刺激（NMES）诱导的肌肉收缩是否有效地产生脑源性神经营养因子（BDNF）。健康的正常受试者参与了本研究。通过初步的实验研究，对运动前后的血乳酸、RER、VE和血清BDNF浓度进行了测定和分析。还需要更多的受试者来总结NMES对BDNF产生的影响，与另一种条件（自愿运动和假刺激）相比，运动期间血清BDNF浓度显示出上升趋势。

项目成果

Time couse changes of trunk muscle activities during sitting in a stable or unstable position

稳定或不稳定坐姿时躯干肌肉活动的时间变化

• 发表时间: 2012
• 作者: Hayami;T.;Kaneko;F.;et. al.
• 通讯作者: et. al.

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The methodological study on the sciatic nerve stimulation by means of transcutaneous magnetic stimulation

经皮磁刺激刺激坐骨神经的方法学研究

• 发表时间: 2012
• 作者: Aoki;N.;Kaneko;F.;et. al.
• 通讯作者: et. al.

神経筋電気刺激の最大刺激強度と漸増時間が筋収縮による関節トルクに及ぼす影響

神经肌肉电刺激最大刺激强度和斜坡上升时间对肌肉收缩引起的关节扭矩的影响

• 发表时间: 2012
• 作者: 竹中 菜々, 川端 佑果;永田 浩三, 鳥橋 茂子;榊善成，金子文成，他
• 通讯作者: 榊善成，金子文成，他

脳機能を理解するための基礎知識

了解大脑功能的基础知识

• 发表时间: 2013
• 作者: Matsumoto Y;Miyazato M;Yokoyama H;Kita M;Hirao Y;Chancellor MB;Yoshimura N.;金子文成
• 通讯作者: 金子文成