Immune regulation of chronic hepatitis B virus infection

慢性乙型肝炎病毒感染的免疫调节

• 批准号: 394568963
• 负责人: Dr. Benedikt Hild
• 金额: --
• 依托单位: Liver Diseases Branch
• 依托单位国家: 德国
• 项目类别: Research Fellowships
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/394568963?language=en
• 关键词: Immune; regulation; chronic; hepatitis; virus

More than 350 million people worldwide are infected with the hepatitis B virus, causing a death toll of approximately 750.000 a year. This makes the hepatitis B virus worldwide one of main causes for liver-associated mortality.A distinct immunologic reaction of the infected individual is essential for the resolving of an acute, self-limiting hepatitis B infection. CD8+-T-cells and the cytokines released by T-cells are known to play a crucial role in this immunologic reaction 3,4. But despite many investigations concerning the immune response during an acute hepatitis B, little is known about the influence of T-cells during a chronic hepatitis B. Additionally the gut microbiome is identified as a major influence on the induction, training and function of the host immune system and thus regulating the extent of systemic inflammation. With the proposed study I would like to investigate the hypothesis that the gut microbiome majorly impacts the intrahepatic immune response during a chronic hepatitis B and thus takes influence on the disease activity and progression. My intention is to investigate the adaptive and innate immune response during different phases of chronic hepatitis B infection und during disease flares in both cross-sectional and prospective patient cohorts.

全球有超过3.5亿人感染乙肝病毒，每年造成的死亡人数约为750.000人。这使得全球范围内的乙肝病毒成为肝脏相关死亡的主要原因之一。感染者的独特免疫反应对于解决急性自限性乙肝感染是至关重要的。CD8+-T细胞和T细胞释放的细胞因子在这一免疫反应中起着至关重要的作用3，4。但是，尽管对急性乙肝期间的免疫反应进行了许多研究，但对T细胞在慢性乙型肝炎中的影响知之甚少。此外，肠道微生物群被认为是对宿主免疫系统的诱导、训练和功能的主要影响，从而调节全身炎症的程度。通过这项拟议的研究，我想要调查一种假设，即肠道微生物群主要影响慢性乙型肝炎期间的肝内免疫反应，从而影响疾病的活动和进展。我的目的是在横断面和前瞻性患者队列中研究慢性乙肝感染不同阶段和疾病暴发期间的适应性和先天免疫反应。

项目成果

TRPC6 channels modulate the response of pancreatic stellate cells to hypoxia

• DOI: 10.1007/s00424-017-2057-0
• 发表时间: 2017-12-01
• 期刊: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
• 影响因子: 4.5
• 作者: Nielsen, Nikolaj;Kondratska, Kateryna;Schwab, Albrecht
• 通讯作者: Schwab, Albrecht

Laboratory mice born to wild mice have natural microbiota and model human immune responses

• DOI: 10.1126/science.aaw4361
• 发表时间: 2019-08-02
• 期刊: SCIENCE
• 影响因子: 56.9
• 作者: Rosshart, Stephan P.;Herz, Jasmin;Rehermann, Barbara
• 通讯作者: Rehermann, Barbara

Is de novo hepatocellular carcinoma after transjugular intrahepatic portosystemic shunt increased?

• DOI: 10.1177/2050640617732886
• 发表时间: 2018-04-01
• 期刊: UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
• 影响因子: 6
• 作者: Husing-Kabar, A.;Meister, T.;Heinzow, H. S.
• 通讯作者: Heinzow, H. S.