Receptor Usage and Regulation of the Immune Response in HSV Infection

HSV 感染中受体的使用和免疫反应的调节

基本信息

项目摘要

Project Description: Herpes simplex virus type I (HSV-1) infection is often asymptomatic or may produce recurrent lesions in and around the mouth, commonly called “cold sores.” Ocular herpetic disease, typically caused by HSV-1 either through primary infection or reactivation from the trigeminal ganglia (TG), can have serious sequelae, including permanent corneal scarring and blindness. Herpes stromal keratitis (HSK) is one of the most common causes of infectious blindness in the developed world, and worldwide produces over 40,000 new cases of severe vision impairment or blindness each year. Interestingly, the majority of HSK tissue damage is thought to be immune-mediated rather than resulting from direct lytic effects of the virus. Even after the virus has successfully been cleared, high levels of inflammatory cytokines and chemokines, immune cell infiltrates, and neovascularization persist. How HSV-1 infection of the eye leads to this chronic inflammatory syndrome is not well understood. By studying cellular factors that influence the host immune response, we will delineate the cascade of events that begin with a viral infection and end with chronic inflammation and vision loss. This proposal represents a continuation of our studies examining cellular factors that are important for HSK using a murine model. The studies proposed here will address the immunomodulatory functions of PILRA and HVEM in Herpes Simplex Virus (HSV) Keratitis. By investigating how PILRA and HVEM contributes to HSK, we will better understand the viral-host interactions inflammatory syndrome that persists in the absence of replicating virus, providing a basis for therapeutic interventions for HSK.
项目描述:

项目成果

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Richard M Longnecker其他文献

Richard M Longnecker的其他文献

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{{ truncateString('Richard M Longnecker', 18)}}的其他基金

Role of Host Cell Factors in Newborn Herpes Simplex Virus (HSV) Encephalitis
宿主细胞因子在新生儿单纯疱疹病毒 (HSV) 脑炎中的作用
  • 批准号:
    10133167
  • 财政年份:
    2019
  • 资助金额:
    $ 23.5万
  • 项目类别:
Role of Host Cell Factors in Newborn Herpes Simplex Virus (HSV) Encephalitis
宿主细胞因子在新生儿单纯疱疹病毒 (HSV) 脑炎中的作用
  • 批准号:
    10369050
  • 财政年份:
    2019
  • 资助金额:
    $ 23.5万
  • 项目类别:
Role of Host Cell Factors in Newborn Herpes Simplex Virus (HSV) Encephalitis
宿主细胞因子在新生儿单纯疱疹病毒 (HSV) 脑炎中的作用
  • 批准号:
    10589755
  • 财政年份:
    2019
  • 资助金额:
    $ 23.5万
  • 项目类别:
Role of Host Cell Factors in Newborn Herpes Simplex Virus (HSV) Encephalitis
宿主细胞因子在新生儿单纯疱疹病毒 (HSV) 脑炎中的作用
  • 批准号:
    9890025
  • 财政年份:
    2019
  • 资助金额:
    $ 23.5万
  • 项目类别:
Role of Host Cell Factors in Herpes Simplex Virus (HSV) Keratitis
宿主细胞因子在单纯疱疹病毒 (HSV) 角膜炎中的作用
  • 批准号:
    8029319
  • 财政年份:
    2011
  • 资助金额:
    $ 23.5万
  • 项目类别:
Role of Host Cell Factors in Herpes Simplex Virus (HSV) Keratitis
宿主细胞因子在单纯疱疹病毒 (HSV) 角膜炎中的作用
  • 批准号:
    8232012
  • 财政年份:
    2011
  • 资助金额:
    $ 23.5万
  • 项目类别:
Discovery of New Treatment Options for EBV-associated Lymphoma and PTLD
发现 EB 病毒相关淋巴瘤和 PTLD 的新治疗方案
  • 批准号:
    8245223
  • 财政年份:
    2008
  • 资助金额:
    $ 23.5万
  • 项目类别:
Discovery of New Treatment Options for EBV-associated Lymphoma and PTLD
发现 EB 病毒相关淋巴瘤和 PTLD 的新治疗方案
  • 批准号:
    8267730
  • 财政年份:
    2008
  • 资助金额:
    $ 23.5万
  • 项目类别:
DETERMINATION OF THE IMPORTANCE OF LMP2A IN PRIMARY EBV INFECTION
确定 LMP2A 在原发 EBV 感染中的重要性
  • 批准号:
    7715494
  • 财政年份:
    2008
  • 资助金额:
    $ 23.5万
  • 项目类别:
Discovery of New Treatment Options for EBV-associated Lymphoma and PTLD
发现 EB 病毒相关淋巴瘤和 PTLD 的新治疗方案
  • 批准号:
    8076396
  • 财政年份:
    2008
  • 资助金额:
    $ 23.5万
  • 项目类别:

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