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The role of CDX1 in malignant progression of intestinal tumorigenesis

The role of CDX1 in malignant progression of intestinal tumorigenesis
CDX1在肠道肿瘤发生恶性进展中的作用
批准号:
24650619
负责人:
AOKI Koji
金额:
$2.5万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31

项目摘要

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中文摘要
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英文摘要
I found that CDX1 and CDX2, intestine-specific transcription factors, suppressed malignant progression of intestinal tumorigenesis. Importantly, CDX1 and CDX2 appeared to inhibit stemness of intestinal tumors, suggesting they were novel suppressors of stemness of colon cancer cells.We are going to reveal the mechanisms of controlling stemness of colon cancer cells, aiming to identify therapeutic targets to kill colon cancer stem cells.
期刊论文(5)
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科研奖励(0)
会议论文
In situ differentiation of CD8ααT cells from CD4 T cells in peripheral lymphoid tissues
外周淋巴组织中 CD8ααT 细胞与 CD4 T 细胞的原位分化
DOI: --
发表时间: 2012
期刊: Scientific Reports
影响因子: 4.6
作者: [Nambu Y, Hayashi T, Jang KJ, Aoki K, Mano H, Nakano K, Osato M, Takahashi K, Itoh K, Teramukai S, Komori T, Fujita J, Ito Y, Shimizu A, Sugai M]
通讯作者: Sugai M
Roles of intestine-specific homeoprotein CDX2 in the intestinal epithelial barrier
肠特异性同源蛋白 CDX2 在肠上皮屏障中的作用
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [Aoki K, Iemura S, Okawa K, Tanida I, Kobayashi T, Mimuro H, Takahito S, Sasakawa C, Natume T, Sugai M, Taketo MM]
通讯作者: Taketo MM
ATG7変異体を用いたオートファジーの抑制方法
使用 ATG7 突变体抑制自噬的方法
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: []
通讯作者:
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: []
通讯作者:
Analysis of the molecular mechanisms by which CDX2 supresses colon caner cell proliferation
  • 批准号:
    22790380
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
  • 资助金额:
    $2.5万
  • 财政年份:
    2010
  • 负责人:
    AOKI Koji
  • 依托单位:
Legal and Policy Analysis on the governance of public education under the NCLB Act in U.S.
  • 批准号:
    19330174
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 资助金额:
    $8.15万
  • 财政年份:
    2007
  • 负责人:
    AOKI Koji
  • 依托单位:
Right to Education and Decentralization /Choice in School Governance-comparative study of legal policy in Japan, the United States and Australia
  • 批准号:
    13620027
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $1.28万
  • 财政年份:
    2001
  • 负责人:
    AOKI Koji
  • 依托单位:
海外基金