Effects of Environmental Chemicals on Fetal Blood Brain Barrier

环境化学物质对胎儿血脑屏障的影响

• 批准号: 24651062
• 负责人: MIYAZAKI Wataru
• 金额: $ 2.58万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24651062/
• 关键词: 環境化学物質; 血液脳関門

Environmental chemicals cause several adverse effects on developing brain of fetus. These effects may be caused by direct action of the chemicals to neural cells, but also there is a possibility that the effects are caused by indirect action of them, for example through disruption of blood brain barrier: BBB. In this study, we used in vitro model of BBB and analyzed the effects of the chemicals on BBB using dioxin as model chemical.The exposure of dioxin caused a distraction of BBB permeability in dose dependently. Moreover, dioxin easily passed through BBB and increased the expression of drug metabolizing enzyme; CYP.These results suggested that BBB disruption were caused by environmental chemicals, dioxin, and the adverse effects might cause abnormal brain development.

环境化学物质对胎儿大脑发育有多种不良影响。这些影响可能是由化学物质对神经细胞的直接作用引起的，但也有可能是由它们的间接作用引起的，例如通过破坏血脑屏障：血脑屏障。本研究采用体外血脑屏障模型，以二恶英为模型化学物质，分析化学物质对血脑屏障的影响。二恶英暴露对血脑屏障通透性的影响呈剂量依赖性。二恶英易通过血脑屏障，增加药物代谢酶的表达；CYP。这些结果表明，血脑屏障的破坏是由环境化学物质二恶英引起的，其不良影响可能导致大脑发育异常。