Mechanism Verification of the Action of Environmental Chemicals on Brain Development

在这项研究中，我们探讨了环境化学物质对大脑发育的不利影响的机制。为了阐明化学物质对神经发育的影响机制，我们利用小鼠海马原代培养细胞和人源性神经祖细胞系分析了环境暴露对神经发育的影响。我们观察到一些与神经发育相关的基因表达的变化。此外，我们还进行了暴露于环境化学物质的小鼠实验。在这些研究中，我们观察到暴露引起了一些神经回路的变化和异常行为。这些结果表明，这些化学物质破坏了大脑的结构，使大脑发育异常。

In this study, we investigated the mechanisms of the adverse effects of environmental chemicals on brain development.To clarify the mechanisms of the effects of the chemicals on neural development, we analyzed that what kind of effects were exerted by exposure of environmental using mice hippocampus primary culture cell and human-derived neural progenitor cell line. We observed some changes of gene expression related to neural development. Moreover, we performed mice experiments exposed environmental chemicals. In these study, we observed that the exposure caused several changes of neural circuit and abnormal behaviors. These results suggested that the chemicals disrupt construction of brain and exert abnormal brain development.