Function-determining Excited-State Dynamics in Transition-Metal Complex-Based Photodrugs in a Cellular Environment

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Contemporary research on photophysics and photochemistry of transition metal complexes involves the investigation of these systems as photoactive drugs. In addition to the plethora of synthetic, biological and pharmacological challenges associated with the design of novel transition metal complex-based photodrugs and their anticipated application, e.g., as anti-inflammatory or anti-cancer drugs, a central photophysical question is prevalent: How does the local environment in a life cell (or even more specifically: in specific compartments of a cell) impact the ultrafast function-determining photoinduced excited-state dynamics in such transition metal complexes? This project will develop experimental spectroscopic tools hand in hand with routines for statistical data analysis to answer this central question. The steps to be taken towards deciphering the ultrafast photoinduced processes of complexes inside cells will present the inherently important next photophysical step towards understanding the structure-dynamics-function relationship in this class of photoactive metal complexes.