Function-determining Excited-State Dynamics in Transition-Metal Complex-Based Photodrugs in a Cellular Environment

细胞环境中基于过渡金属配合物的光药物的功能决定激发态动力学

• 批准号: 395358570
• 负责人: Professor Dr. Thomas Bocklitz
• 金额: --
• 依托单位: Arbeitsgruppe Molekulare Photonik
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/395358570?language=en
• 关键词: Function; determining; Excited; State; Dynamics

Contemporary research on photophysics and photochemistry of transition metal complexes involves the investigation of these systems as photoactive drugs. In addition to the plethora of synthetic, biological and pharmacological challenges associated with the design of novel transition metal complex-based photodrugs and their anticipated application, e.g., as anti-inflammatory or anti-cancer drugs, a central photophysical question is prevalent: How does the local environment in a life cell (or even more specifically: in specific compartments of a cell) impact the ultrafast function-determining photoinduced excited-state dynamics in such transition metal complexes? This project will develop experimental spectroscopic tools hand in hand with routines for statistical data analysis to answer this central question. The steps to be taken towards deciphering the ultrafast photoinduced processes of complexes inside cells will present the inherently important next photophysical step towards understanding the structure-dynamics-function relationship in this class of photoactive metal complexes.

过渡金属配合物的光物理和光化学的当代研究涉及这些系统作为光活性药物的研究。除了与基于新型过渡金属络合物的光药物的设计及其预期应用相关的过多的合成、生物学和药理学挑战之外，作为抗炎或抗癌药物，一个中心的生物物理问题是普遍存在的：生命细胞中的局部环境（或甚至更具体地说：在细胞的特定区室中）如何影响这种过渡金属络合物中决定超快功能的光诱导激发态动力学？这个项目将开发实验光谱工具，并与统计数据分析程序一起回答这个中心问题。对破译细胞内的复合物的超快光诱导过程所采取的步骤将呈现出固有的重要的下一个物理步骤，以了解这类光活性金属复合物的结构-动力学-功能关系。