Designing and imaging of reconstructed muscle using DNA nanostructure

我们的目标是通过构建由蛋白质和DNA分子组成的人工肌肉，并在单分子分辨率下观察其动力学，来阐明肌肉的节能、灵活性和适应性机制。我成功地构建了亚微米尺寸的人工马达蛋白组装体。通过这个实验，我确认了控制马达分子数量和间距的方法。这种新的方法使我们能够分析生命独特属性的出现机制。

Our goal is to clarify the mechanism of energy-saving, flexibility and adaptability of muscle by creating an artificial muscle made of proteins and DNA molecules and observing the dynamics at the single molecule resolution.I used DNA nanotechnology called DNAorigami and the nanosized modules were hybridized with motor protein molecules. I succeeded in constructing the artificial motor protein assembly with sub-micrometer size. Through this experiment, I confirmed the methodology for controlling the number and spacing of motor molecules. This novel methodologies enables us to analyze the emergence mechanism of unique properties of life.