Mechanical control of the Brownian process for bio nano-motors

我建立了暗视野显微镜结合光阱的单分子测量。利用该装置，我成功地直接观察了生物纳米马达myosin-V步进运动中的布朗搜索过程，并对该过程进行了机械控制。停留时间分析、布朗过程的噪声分析和负载依赖性分析使我们能够从机械功能中热噪声滚动的角度来建模生物纳米电机。这是一个重要的结果，对控制纳米机器使用噪声，如随机共振。

I constructed the dark-field microscopy combined with an optical trap for the single molecule measurements. Using this apparatus, I succeeded in both direct observation of Brownian search process in the stepping motion of bio nano-motor, myosin-V and mechanical control of the process. Dwell time analysis, noise analysis for the Brownian process and the load dependency enabled us to model bio nano-motor from a viewpoint of the roll of thermal noise in mechanical function. This is an important result toward control of nano-machine using noise such as stochastic resonance.