Catalytic Synthesis of a Chiral Silicon Center

与手性碳中心相比，手性硅中心的化学性质尚未得到充分的研究，这主要是由于缺乏构建手性硅中心的方法。本研究的目的是在我们之前报道的铑催化合成苯甲硅的基础上，开发一种生成手性硅中心的催化方法。我们发现含有异丙基二甲基硅基的底物被采用，较小的甲基被完全切割，并且通过添加手性膦配体形成具有手性硅中心的苯甲硅酮，可以对两个对映体甲基进行对映选择性切割。

Chemistry of chiral silicon centers remain unexplored, when compared to that of chiral carbon centers, mainly due to the lack of methods for the construction of chiral silicon centers. The purpose of this study is to develop a catalytic method for the generation of chiral silicon centers on the basis of rhodium-catalyzed synthesis of benzosiloles, which we reported previously. We found that the substrate containing an isopropyldimethylsilyl group was employed, a less bulky methyl group is cleaved exclusively, and enantioselective cleavage of two enantiotopic methyl groups was possible by adding a chiral phosphine ligand to form a benzosilole bearing a chiral silicon center.