Catalytic Synthesis of a Chiral Silicon Center

与手性碳中心相比，手性硅中心的化学仍未被探索，这主要是由于缺乏构建手性硅中心的方法。本研究的目的是在我们先前报道的催化合成苯并硅烷的基础上，发展一种生成手性硅中心的催化方法。我们发现，使用了含有异丙基二甲基硅基的底物，专一性地切割了体积较小的甲基，通过添加手性膦配体形成含手性硅中心的苯并硅分子，可以对两个对映体甲基进行对映选择性切割。

Chemistry of chiral silicon centers remain unexplored, when compared to that of chiral carbon centers, mainly due to the lack of methods for the construction of chiral silicon centers. The purpose of this study is to develop a catalytic method for the generation of chiral silicon centers on the basis of rhodium-catalyzed synthesis of benzosiloles, which we reported previously. We found that the substrate containing an isopropyldimethylsilyl group was employed, a less bulky methyl group is cleaved exclusively, and enantioselective cleavage of two enantiotopic methyl groups was possible by adding a chiral phosphine ligand to form a benzosilole bearing a chiral silicon center.