Real-time Observation of Dynamics of Vitreous Body

实时观察玻璃体动态

• 批准号: 24655103
• 负责人: ANNAKA MASAHIKO
• 金额: $ 2.58万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24655103/
• 关键词: 硝子体; ダイナミクス; 動的光散乱; バイオハイドロゲル; 相挙動

From the observations of the dynamics of light scattered by the pig vitreous body, intensity autocorrelation functions that revealed two diffusion coefficients, D(fast) and D(slow), were obtained. We developed the theory for describing the density fluctuation of the entities in the vitreous gel system with Na-hyaluronate polymers filled in the meshes of collagen fiber network. The dynamics of collagen and Na-hyaluronate explains two relaxation modes of the fluctuation. The diffusion coefficient of collagen obtained from D(fast) and D(slow) is very close to that in aqueous solution, which suggests the vitreous body is in the swollen state. The diffusion coefficients were found to be dependent on the position (surface or central part) of the vitreous body from which the scattered light sampled. The inhomogeneous distribution of Na-hyaluronate and collagen and the shell structure of the vitreous body were suggested.

从猪玻璃体散射光的动态观察，强度自相关函数，揭示了两个扩散系数，D（快）和D（慢），得到。 我们发展了描述玻璃体凝胶系统中实体密度波动的理论，其中透明质酸钠聚合物填充在胶原纤维网络的网格中。胶原和透明质酸钠的动力学解释了波动的两种弛豫模式。从D（快）和D（慢）获得的胶原扩散系数非常接近于在水溶液中的扩散系数，这表明玻璃体处于溶胀状态。扩散系数被认为是依赖于位置（表面或中心部分）的玻璃体从散射光采样。 提示玻璃体内玻璃酸钠和胶原分布不均匀，玻璃体呈壳状结构。

项目成果

Dynamic Light Scattering Study of Salt Effect on Phase Behavior of Pig Vitreous Body and Its Microscopic Implication

盐对猪玻璃体相行为影响的动态光散射研究及其微观意义

• 期刊: Journal of Physical Chemistry (in press)
• 作者: M.Annaka;M.Okamoto;T.Matsuura;Y.Hara;S.Sasaki
• 通讯作者: S.Sasaki

Salt effect on microscopic structure and stability of colloidal complex obtained from neutral/polyelectrolyte block copolymer and oppositely charged surfactant

盐对中性/聚电解质嵌段共聚物与带相反电荷的表面活性剂胶体复合物微观结构和稳定性的影响

• 发表时间: 2013
• 期刊: Colloid and Surface B
• 作者: A. Shundo;K. Hori;D. P. Penaloza Jr.;K. Yoshihiro;M. Annaka;K. Tanaka;Masahiko Annaka
• 通讯作者: Masahiko Annaka

有機−無機ハイブリッドゲルの眼内レンズへの展開

有机-无机混合凝胶人工晶状体的开发

• 发表时间: 2013
• 作者: T. Matsuura;M. Annaka;M. Kojima;K. Shimoyama;Y. Hara;辻聡一郎,安中雅彦;辻聡一郎,Kell Moetensen,安中雅彦;辻聡一郎,安中雅彦
• 通讯作者: 辻聡一郎,安中雅彦

有機-無機ハイブリッドゲルの眼内レンズへの展開

有机-无机混合凝胶人工晶状体的开发

• 发表时间: 2012
• 作者: M. Annaka;K. Mortensen;Toyoaki Matsuura;H. Tsujinaka and N. Ogata;伊藤真也，村岡幸恵，Kell Mortensen，安中雅彦;伊藤真也，村岡幸恵，安中雅彦
• 通讯作者: 伊藤真也，村岡幸恵，安中雅彦

両末端を疎水化した感温性高分子のダイナミクス

疏水端热敏聚合物的动力学

• 发表时间: 2014
• 作者: T. Matsuura;M. Annaka;M. Kojima;K. Shimoyama;Y. Hara;辻聡一郎,安中雅彦
• 通讯作者: 辻聡一郎,安中雅彦