19F-MR Imaging of Nucleic Acids based on Photochemically Hyperpolarlized Nuclear Spins

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In vivo imaging technologies, such as X-ray computed tomography, positron emission tomography, and nuclear magnetic resonance imaging, are promising technologies for diagnosis of various disorders and follow up after surgical treatments. Due to the low background signal of 19 F MR in vivo, these 19F MR based imaging probes have potential for high contrast and specific imaging of target biomolecules. However, molecular 19F probes that can image nucleic acids have been scarcely reported, because of low sensitivity of 19F MR signal. As the method that can tremendously enhance the MR signal of 19F nuclei by using of parahydrogen-induced hyperpolarization (PHIP) of 19F nuclei. So, 19F-MR imaging of DNA based on photochemically generalized parahydrogen caused from cyclobutane dimer by DNA crosslinking was investigated.