Development of a manufacturing process for textile biomimetic reinforcement structures, based on the example of an aortic valve replacement

以主动脉瓣置换术为例，开发纺织仿生加固结构的制造工艺

• 批准号: 395116303
• 负责人: Professor Dr. Stefan Jockenhövel
• 金额: --
• 依托单位: Lehrstuhl für Medizintechnische Materialien und Implantate
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/395116303?language=en
• 关键词: Development; manufacturing; process; textile; biomimetic

Most native tissue provides anisotropic mechanical properties that are based on load-oriented fibres. This load-oriented anisotropy is highly relevant for the long-term stability of the corresponding tissue. It is still a great challenge to consider this complex behaviour during the development of tissue replacement structures. Within the project a process to manufacture biomimetic reinforced scaffolds on the example of a biohybrid aortic valve replacement is developed and evaluated. The scaffold is realized as a composite structure containing fibres and hydrogel as specified below:(i) Placement of load-oriented fibres using a winding-process,(ii) fixation of fibre-placement via electrospinning and(iii) embedding of textile reinforcement structure in a fibrin-hydrogel-matrix as scaffold for in-vitro or in-vivo biologization for a biohybrid implant.Using the newly developed technology for the application as aortic valve replacement the following advantages are expected:(iv) physiological valve opening and closing behaviour(v) high load capacity of the composite suitable for the application in the systemic circulation (aortic and mitral valve) as well as a(vi) high long-term stability of the implant.

大多数天然组织具有基于负载取向纤维的各向异性力学性能。这种负载取向的各向异性与相应组织的长期稳定性高度相关。在组织替代结构的发展过程中考虑这种复杂的行为仍然是一个巨大的挑战。在该项目中，以生物混合主动脉瓣置换术为例，开发和评估了制造仿生增强支架的过程。支架实现为包含纤维和水凝胶的复合结构，如下所述：(i)使用缠绕工艺放置负载定向纤维，（ii）通过静电纺丝固定纤维放置，（iii）将纺织增强结构嵌入纤维-水凝胶基质中，作为用于生物杂交植入物体外或体内生物化的支架。将新开发的技术应用于主动脉瓣置换术，预期具有以下优点：（iv）生理瓣膜的开启和关闭行为(v)适用于体循环（主动脉瓣和二尖瓣）的复合材料的高负荷能力以及（vi）植入物的高长期稳定性。