Development of a Taylor vortex flow bioreactor which is suitable for the cultivation and mixing of animal cells such as the undifferentiated cells easily destroyed in a shearing flow region

泰勒涡流生物反应器的研制，适合剪切流区易破坏的未分化细胞等动物细胞的培养和混合

• 批准号: 24656116
• 负责人: KAWAI Hideki
• 金额: $ 1.83万
• 依托单位: Muroran Institute of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24656116/
• 关键词: Ｔａｙｌｏｒ渦; 固気液分離; カオス; 混相流; 微生物流動; 超音波ドップラ流速計; Taylor渦; 固液分離

Bioreactors are one of the practical applications for an Taylor Vortex Flow system(TVF) which enables a milder mixing process protecting the animal cell like an indifferent cell from the damage of higher share flows. The TVF system with a small aspect ratio has characteristics of spectrum chaotic complicated flow with an Ekman boundary layer near the upper and lower boundaries.In the present, we study the mixing effect of the TVF on uniformizing the immobilization of microorganism to the carriers. As the results, the distribution of the immobilization rate to the Bio supported polymers(BSPs) is much uniform with using the TVF bioreactor system compared with the previous aeration mixing method which is often used in the bio-mixing process. On the contrary, the immobilized absolute rate is much more in the aeration method, which is the current problem of the TVF system.

生物反应器是泰勒涡流系统 (TVF) 的实际应用之一，该系统能够实现更温和的混合过程，保护动物细胞（如中性细胞）免受更高份额流动的损害。小长径比的TVF系统具有谱混沌复杂流的特点，在上下边界附近有Ekman边界层。目前，我们研究了TVF对微生物均匀固定于载体的混合作用。结果，与生物混合过程中常用的之前的曝气混合方法相比，使用TVF生物反应器系统对生物支持聚合物（BSP）的固定率分布更加均匀。相反，曝气法的固定化绝对率要高得多，这是目前TVF系统存在的问题。

项目成果

Crack Propagation and Remaining Life Assessment of Coke Drums Due to Thermal Stresses

热应力引起的焦炭塔裂纹扩展和剩余寿命评估

• 发表时间: 2012
• 期刊: Journal of Thermal Stresses
• 影响因子: 2.8
• 作者: H. Ambarita;M. Daimaruya;H. Fujiki;H. Kawai;H. Kobayashi and M. Oka
• 通讯作者: H. Kobayashi and M. Oka

バイオディーゼル燃料の粘度物性とGC による精油過程の評価

生物柴油燃料的粘度特性及气相色谱法评价炼油工艺

• 发表时间: 2014
• 作者: 三好宗幸,河合秀樹;村川英樹,木倉宏成;三木千純,河合秀樹
• 通讯作者: 三木千純,河合秀樹

バイオディーゼル燃料の粘度物性とGCによる精油過程の評価

生物柴油燃料的粘度特性及气相色谱法评价炼油工艺

• 发表时间: 2014
• 作者: 三好宗幸,河合秀樹;村川英樹,木倉宏成;三木千純,河合秀樹;鎌田宗幸，河合秀樹，鈴木淳，熊谷建次，埜上 洋;三木千純，河合秀樹
• 通讯作者: 三木千純，河合秀樹

Numerical Analysis of a Taylor-Couette Vortex Flow at High Reynolds number

高雷诺数泰勒-库埃特涡流的数值分析

• 发表时间: 2013
• 作者: 三好宗幸,河合秀樹;村川英樹,木倉宏成;三木千純,河合秀樹;鎌田宗幸，河合秀樹，鈴木淳，熊谷建次，埜上 洋;三木千純，河合秀樹;三好宗幸，河合秀樹， 村川英樹，木倉宏成;小林裕平，河合秀樹;河合秀樹,菅佑介;山田雄大,河合秀樹;赤沢悠太,河合秀樹;Hideki Kawai;Yuta Akazawa and Hideki Kawai
• 通讯作者: Yuta Akazawa and Hideki Kawai

DEM analysis on powder behavior passing through an orifice that consists of coarse particles

对通过粗颗粒孔口的粉末行为进行 DEM 分析

• 发表时间: 2013
• 作者: Masahiro Fukuda;Jun Suzuki;Hiroshi Nogami and Hideki Kawai
• 通讯作者: Hiroshi Nogami and Hideki Kawai