Development of a Taylor vortex flow bioreactor which is suitable for the cultivation and mixing of animal cells such as the undifferentiated cells easily destroyed in a shearing flow region

生物反应器是Taylor Vortex Flow系统（TVF）的实际应用之一，其能够实现更温和的混合过程，保护动物细胞（如无关细胞）免受更高份额流的损害。小长径比的TVF系统具有频谱混沌复杂流动的特点，在上下边界附近存在Ekman边界层，本文研究了TVF对微生物均匀固定化的混合作用。结果表明，与传统的曝气混合法相比，TVF生物反应器系统固定化率在生物负载聚合物（BSPs）上的分布更加均匀。而曝气法的固定化绝对速率较大，这是目前TVF系统存在的问题。

Bioreactors are one of the practical applications for an Taylor Vortex Flow system(TVF) which enables a milder mixing process protecting the animal cell like an indifferent cell from the damage of higher share flows. The TVF system with a small aspect ratio has characteristics of spectrum chaotic complicated flow with an Ekman boundary layer near the upper and lower boundaries.In the present, we study the mixing effect of the TVF on uniformizing the immobilization of microorganism to the carriers. As the results, the distribution of the immobilization rate to the Bio supported polymers(BSPs) is much uniform with using the TVF bioreactor system compared with the previous aeration mixing method which is often used in the bio-mixing process. On the contrary, the immobilized absolute rate is much more in the aeration method, which is the current problem of the TVF system.