Effects of visual deprivation on neuronal processing in auditory cortex

视觉剥夺对听觉皮层神经元处理的影响

基本信息

  • 批准号:
    23500402
  • 负责人:
  • 金额:
    $ 3.33万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    2011
  • 资助国家:
    日本
  • 起止时间:
    2011 至 2013
  • 项目状态:
    已结题

项目摘要

In this research project, we examined whether the loss of eye sight affects cortical neurons in auditory cortex using mice as a model. In an electrophysiological examination of cortical neurons in primary auditory cortex that receive direct auditory thalamic inputs, we found that the regulation of neuronal excitability by the neurotransmitter acetylcholine is compromised by visual loss, while intrinsic membrane properties of them were largely unaffected. Further, in the auditory cortex of blind mice, sound stimulation elicited little activation of regulatory proteins of gene expression, while they are clearly activated in sighted control mice. These results suggest that neuronal functions in auditory cortex change due to the loss of eye sight during development and raise the possibility that sensory loss changes neuronal properties in the cortex of different modality.
在本研究项目中,我们以小鼠为模型,研究了视力丧失是否会影响听觉皮层的皮层神经元。在接受直接听觉丘脑输入的初级听觉皮层中的皮层神经元的电生理检查中,我们发现神经递质乙酰胆碱对神经元兴奋性的调节受到视觉丧失的影响,而它们的内在膜特性在很大程度上不受影响。此外,在盲人小鼠的听觉皮层中,声音刺激几乎没有引起基因表达调节蛋白的激活,而在视力正常的对照小鼠中,它们明显被激活。这些结果表明,听觉皮层的神经元功能的变化,由于在发展过程中的眼睛视力的损失,并提高感觉损失的可能性,改变不同形式的皮层神经元的特性。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
一次聴覚皮質3/4層錐体細胞におけるコリン作動性反応の視覚剥奪による下降調節
视觉剥夺诱导初级听觉皮层 3/4 层锥体细胞胆碱能反应的下行调节
  • DOI:
  • 发表时间:
    2013
  • 期刊:
  • 影响因子:
    0
  • 作者:
    鈴木俊雄;川井秀樹
  • 通讯作者:
    川井秀樹
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KAWAI Hideki其他文献

KAWAI Hideki的其他文献

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{{ truncateString('KAWAI Hideki', 18)}}的其他基金

Development of bioimaging by near-infrared to visible up-conversion
近红外到可见光上转换生物成像的发展
  • 批准号:
    15K14938
  • 财政年份:
    2015
  • 资助金额:
    $ 3.33万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Measurement of the flow field in Taylor vortex with using the ultrasound velocimetry and application to the bioreactor system protecting the bio cells from the powered sharing flow
使用超声测速法测量泰勒涡流中的流场并应用于生物反应器系统,保护生物细胞免受动力共享流的影响
  • 批准号:
    26420096
  • 财政年份:
    2014
  • 资助金额:
    $ 3.33万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Development of a Taylor vortex flow bioreactor which is suitable for the cultivation and mixing of animal cells such as the undifferentiated cells easily destroyed in a shearing flow region
泰勒涡流生物反应器的研制,适合剪切流区易破坏的未分化细胞等动物细胞的培养和混合
  • 批准号:
    24656116
  • 财政年份:
    2012
  • 资助金额:
    $ 3.33万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Development of a bioreactor with high growth efficiency for an indifferent cellar as a stem cell by using the chaos mixing Taylor vortex flow
利用混沌混合泰勒涡流开发具有高生长效率的生物反应器,用于作为干细胞的冷漠地窖
  • 批准号:
    21560163
  • 财政年份:
    2009
  • 资助金额:
    $ 3.33万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Development of photosensitized dendrimers for laser medium
用于激光介质的光敏树枝状聚合物的开发
  • 批准号:
    20550121
  • 财政年份:
    2008
  • 资助金额:
    $ 3.33万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Application of a chaos mixing Taylor vortex flow for the two phase flow in bioreactors, and the flow analysis for approaching the blood filtration
混沌混合泰勒涡流在生物反应器中两相流的应用及接近血液过滤的流动分析
  • 批准号:
    19560156
  • 财政年份:
    2007
  • 资助金额:
    $ 3.33万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Development of light emitting devices using artificial photonic synthesis model dendrimers
使用人工光子合成模型树枝状聚合物开发发光器件
  • 批准号:
    18550122
  • 财政年份:
    2006
  • 资助金额:
    $ 3.33万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
The analysis of a chaotic mixing method with a Taylor vortex flow and the possibility to a blood filtration system and a photo-bioreactor.
泰勒涡流混沌混合方法的分析以及血液过滤系统和光生物反应器的可能性。
  • 批准号:
    17560133
  • 财政年份:
    2005
  • 资助金额:
    $ 3.33万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
The possibility of the blood filtration and photo-bioreactor with the Taylor chaotic mixing vortex.
泰勒混沌混合涡流的血液过滤和光生物反应器的可能性。
  • 批准号:
    15560127
  • 财政年份:
    2003
  • 资助金额:
    $ 3.33万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
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