A Study on a fluoerescense correlation spectroscopy based glyco chip using multiple-tap charge modulators.

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The final target of this study is the development of a portable low-cost glyco-chip for diagnosing the early stage of infectious disease. Toward this goal, a technique using semiconductor-based fluorescence correlation spectroscopy (FCS) for detecting the biding of glycoprotein and virus is investigated. To demonstrate it, a prototype CMOS image sensor chip using a new 4-tap photo-charge modulator with lateral electric field control has been designed with device simulations and implemented using 0.11μm CMOS image sensor technology.