Analysis of the regulation of asymmetric cell division by using the artificially induced polarization of HeLa cells.

点击翻译按钮获取中文摘要

Asymmetric cell division is an important mechanism that regulates growth or differentiation of stem cells. In this project, we tried to reveal the role of important factors in asymmetric cell division by using the artificially induced polarization of HeLa cells, in which expressed the chimera molecules between Echinoid, an cell-cell adhesion molecule, and a factor, which activates the polarization signal pathway. We found that ROCO family kinase LRRK1 plays an important role in the control of the axis of cell division by regulating the mitotic spindle.