Analysis of the spatiotemporal regulation of EGFR signal by LRRK1

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Excess signal from EGFR leads to tumorigenesis. We reveal that LRRK1 regulates EGFR signal spatiotemporally through the regulation of intracellular trafficking of EGFR. Our findings indicate that (1) LRRK1 regulates EGFR transport from early to late endosomes, and (2) LRRK1 regulates efficient sorting of EGFR to the inner vesicles of endosome by interacting with STAM1, a component of ESCRT-0 complex. Furthermore, LRRK1 plays an important role in the initiation of EGFR trafficking by phosphorylating CLIP-170.