Biosynthtic investigation of the didemnins

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The antitumor peptide didemnins originally found from the Caribbean tunicate Trididemnum solidum were recently identified in the cultured marine bacterium Tistrella mobilis collected in various regions in the world. We thus compared the production and genetic profiles between the tunicate and the microbe. We found that the metabolic pattern in the bacteria differed largely from that of the tunicate. Analysis of microbial fauna in the tunicate indicated that a genus of cyanobacteria is a main associate of the tunicate, but T. mobilis was found as only a minor microbe that associate with the host.