Biosynthtic investigation of the didemnins

抗肿瘤肽dideminins最初发现于加勒比海被囊动物Trididemnum solidum，最近在世界各地收集的培养海洋细菌Tistrella mobilis中发现。因此，我们比较了被囊动物和微生物之间的生产和遗传谱。我们发现细菌的代谢模式与被囊动物的代谢模式有很大的不同。对被囊动物的微生物区系分析表明，蓝藻属是被囊动物的主要伴生菌，而移动绦虫仅是与宿主伴生的次要微生物。

The antitumor peptide didemnins originally found from the Caribbean tunicate Trididemnum solidum were recently identified in the cultured marine bacterium Tistrella mobilis collected in various regions in the world. We thus compared the production and genetic profiles between the tunicate and the microbe. We found that the metabolic pattern in the bacteria differed largely from that of the tunicate. Analysis of microbial fauna in the tunicate indicated that a genus of cyanobacteria is a main associate of the tunicate, but T. mobilis was found as only a minor microbe that associate with the host.